Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1790505..1791138 Replicon chromosome
Accession NZ_CP019610
Organism Mycobacterium tuberculosis strain H54

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag B0W97_RS08830 Protein ID WP_003403365.1
Coordinates 1790755..1791138 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag B0W97_RS08825 Protein ID WP_003403368.1
Coordinates 1790505..1790660 (+) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W97_RS08795 1785622..1787985 - 2364 WP_003901895.1 arylsulfatase AtsD -
B0W97_RS08800 1788099..1788353 + 255 WP_003911263.1 antitoxin VapB7 -
B0W97_RS08805 1788350..1788787 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
B0W97_RS08810 1788897..1789142 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
B0W97_RS08815 1789129..1789437 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
B0W97_RS08820 1789713..1790429 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
B0W97_RS08825 1790505..1790660 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B0W97_RS08830 1790755..1791138 + 384 WP_003403365.1 ribonuclease VapC6 Toxin
B0W97_RS08835 1791526..1792536 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
B0W97_RS08840 1792617..1794122 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -
B0W97_RS08845 1794193..1794888 + 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
B0W97_RS08850 1794881..1795273 - 393 WP_003403353.1 50S ribosomal protein L7/L12 -
B0W97_RS08855 1795310..1795846 - 537 WP_003403341.1 50S ribosomal protein L10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T72841 WP_003403365.1 NZ_CP019610:1790755-1791138 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T72841 NZ_CP019610:1790755-1791138 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT72841 WP_003403368.1 NZ_CP019610:1790505-1790660 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT72841 NZ_CP019610:1790505-1790660 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References