Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 1788350..1789142 Replicon chromosome
Accession NZ_CP019610
Organism Mycobacterium tuberculosis strain H54

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag B0W97_RS08805 Protein ID WP_003403386.1
Coordinates 1788350..1788787 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag B0W97_RS08810 Protein ID WP_003403381.1
Coordinates 1788897..1789142 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W97_RS08780 1784813..1784986 - 174 WP_003898549.1 hypothetical protein -
B0W97_RS08785 1784983..1785321 - 339 WP_003403405.1 PIN domain-containing protein -
B0W97_RS08790 1785233..1785559 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
B0W97_RS08795 1785622..1787985 - 2364 WP_003901895.1 arylsulfatase AtsD -
B0W97_RS08800 1788099..1788353 + 255 WP_003911263.1 antitoxin VapB7 -
B0W97_RS08805 1788350..1788787 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
B0W97_RS08810 1788897..1789142 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
B0W97_RS08815 1789129..1789437 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
B0W97_RS08820 1789713..1790429 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
B0W97_RS08825 1790505..1790660 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
B0W97_RS08830 1790755..1791138 + 384 WP_003403365.1 ribonuclease VapC6 -
B0W97_RS08835 1791526..1792536 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
B0W97_RS08840 1792617..1794122 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T72839 WP_003403386.1 NZ_CP019610:1788350-1788787 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T72839 NZ_CP019610:1788350-1788787 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT72839 WP_003403381.1 NZ_CP019610:1788897-1789142 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT72839 NZ_CP019610:1788897-1789142 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References