Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 352499..353043 Replicon chromosome
Accession NZ_CP019610
Organism Mycobacterium tuberculosis strain H54

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag B0W97_RS01780 Protein ID WP_003409896.1
Coordinates 352747..353043 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag B0W97_RS01775 Protein ID WP_003409899.1
Coordinates 352499..352750 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W97_RS01740 348226..349023 - 798 WP_003899101.1 ABC transporter permease -
B0W97_RS01755 349922..351142 + 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
B0W97_RS01760 351175..351447 + 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
B0W97_RS01765 351451..351858 + 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
B0W97_RS01770 352018..352512 - 495 WP_003899099.1 hypothetical protein -
B0W97_RS01775 352499..352750 + 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
B0W97_RS01780 352747..353043 + 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B0W97_RS01785 353092..353706 + 615 WP_003901296.1 hypothetical protein -
B0W97_RS01790 353595..354140 - 546 WP_003409891.1 SecB-like chaperone -
B0W97_RS01795 354137..354586 - 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
B0W97_RS01800 354628..355005 - 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
B0W97_RS21595 354980..355501 + 522 WP_003904745.1 hypothetical protein -
B0W97_RS01810 355475..355786 - 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
B0W97_RS01815 355783..355998 - 216 WP_003409878.1 antitoxin -
B0W97_RS01820 356238..356534 + 297 WP_003409877.1 hypothetical protein -
B0W97_RS01825 356535..356726 + 192 WP_003409876.1 hypothetical protein -
B0W97_RS01830 356747..357649 + 903 WP_003899097.1 hypothetical protein -
B0W97_RS01835 357660..358010 + 351 WP_003409871.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T72823 WP_003409896.1 NZ_CP019610:352747-353043 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T72823 NZ_CP019610:352747-353043 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT72823 WP_003409899.1 NZ_CP019610:352499-352750 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT72823 NZ_CP019610:352499-352750 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References