Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 293558..294199 Replicon chromosome
Accession NZ_CP019610
Organism Mycobacterium tuberculosis strain H54

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag B0W97_RS01440 Protein ID WP_003410075.1
Coordinates 293558..293956 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WLM7
Locus tag B0W97_RS01445 Protein ID WP_003899127.1
Coordinates 293957..294199 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0W97_RS01390 288564..288839 - 276 WP_016330411.1 hypothetical protein -
B0W97_RS01400 289157..290413 + 1257 WP_003902247.1 HNH endonuclease -
B0W97_RS01405 290541..291131 - 591 WP_003899131.1 IS110 family transposase -
B0W97_RS01410 291085..291732 - 648 WP_071854215.1 transposase -
B0W97_RS01415 291793..291972 + 180 Protein_276 hypothetical protein -
B0W97_RS01430 292409..292903 - 495 WP_003410080.1 DUF1398 domain-containing protein -
B0W97_RS01435 292944..293375 + 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
B0W97_RS01440 293558..293956 - 399 WP_003410075.1 PIN domain nuclease Toxin
B0W97_RS01445 293957..294199 - 243 WP_003899127.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B0W97_RS01450 294287..295612 + 1326 WP_003410070.1 DUF4143 domain-containing protein -
B0W97_RS01455 295801..296145 + 345 WP_003410065.1 ferredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(7-48)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T72819 WP_003410075.1 NZ_CP019610:c293956-293558 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T72819 NZ_CP019610:c293956-293558 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8851.73 Da        Isoelectric Point: 4.1621

>AT72819 WP_003899127.1 NZ_CP019610:c294199-293957 [Mycobacterium tuberculosis]
VYSGVVSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 243 bp

>AT72819 NZ_CP019610:c294199-293957 [Mycobacterium tuberculosis]
GTGTATAGTGGTGTTGTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACT
CGATTCCAAGCGAAGTGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGC
TGCAGGGCAGCGGTTTCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
PDB 4CHG
AlphaFold DB A0A045JPF9

References