Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 1222856..1223420 Replicon chromosome
Accession NZ_CP019609
Organism Vagococcus penaei strain CD276T

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BW732_RS05670 Protein ID WP_077275873.1
Coordinates 1223085..1223420 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BW732_RS05665 Protein ID WP_077275872.1
Coordinates 1222856..1223092 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW732_RS11335 1218058..1218228 - 171 WP_152023777.1 HAD hydrolase family protein -
BW732_RS05645 1218321..1219508 - 1188 WP_077275868.1 MFS transporter -
BW732_RS05650 1219754..1219936 - 183 WP_077275869.1 ammonium transporter -
BW732_RS05655 1220254..1221123 - 870 WP_077275870.1 VOC family protein -
BW732_RS05660 1221330..1222733 + 1404 WP_077275871.1 C69 family dipeptidase -
BW732_RS05665 1222856..1223092 + 237 WP_077275872.1 hypothetical protein Antitoxin
BW732_RS05670 1223085..1223420 + 336 WP_077275873.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BW732_RS05675 1223504..1224940 - 1437 WP_077275874.1 PLP-dependent aminotransferase family protein -
BW732_RS05680 1225063..1225899 + 837 WP_179946089.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
BW732_RS05685 1225886..1226440 + 555 WP_077275875.1 ECF transporter S component -
BW732_RS05690 1226544..1227062 - 519 WP_077275876.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
BW732_RS05695 1227104..1227706 - 603 WP_126844442.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12891.87 Da        Isoelectric Point: 8.8167

>T72814 WP_077275873.1 NZ_CP019609:1223085-1223420 [Vagococcus penaei]
MTKPHIPHKGDIVWIDFDPSTGVEIKKRRPALVVSNYDFNLSTKFAIVCPITSTEKNYPTRYNLAKDYQTKGQVVISQIK
SLDYTQRHVEFIERIHASDLTMIDQIMAYIF

Download         Length: 336 bp

>T72814 NZ_CP019609:1223085-1223420 [Vagococcus penaei]
ATGACTAAACCACATATTCCGCATAAAGGAGATATTGTTTGGATTGACTTTGACCCTTCAACGGGTGTAGAAATAAAAAA
ACGTCGTCCTGCCTTAGTTGTGTCCAACTACGACTTTAATTTATCAACTAAATTTGCGATTGTCTGTCCCATCACATCAA
CTGAAAAAAACTACCCAACACGTTATAATCTAGCAAAAGACTACCAAACGAAAGGACAAGTCGTAATCTCGCAAATCAAA
TCACTCGACTACACCCAGCGTCATGTTGAATTTATTGAAAGAATTCATGCCTCTGACTTAACCATGATTGATCAAATTAT
GGCATATATTTTTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8790.88 Da        Isoelectric Point: 4.1064

>AT72814 WP_077275872.1 NZ_CP019609:1222856-1223092 [Vagococcus penaei]
MLETKTQNQGKSVVITLPNAENIELVAGKKYLVTYHENGTIMLTPKIDNPFKDIDEGSFYEADLWEEMTARGGEIIDD

Download         Length: 237 bp

>AT72814 NZ_CP019609:1222856-1223092 [Vagococcus penaei]
ATGCTTGAAACCAAGACCCAAAACCAAGGAAAATCAGTTGTCATCACACTCCCAAACGCTGAAAATATCGAACTAGTCGC
TGGGAAAAAATATCTCGTGACTTATCATGAAAATGGAACTATTATGCTAACCCCAAAAATTGATAACCCCTTTAAAGATA
TAGACGAAGGAAGCTTTTATGAGGCTGATTTATGGGAAGAAATGACTGCTCGTGGAGGCGAAATAATCGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References