Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 160998..161535 Replicon plasmid pCME4A9II
Accession NZ_CP019604
Organism Croceicoccus marinus strain E4A9

Toxin (Protein)


Gene name parE Uniprot ID A0A217EYW6
Locus tag A9D14_RS18340 Protein ID WP_066850845.1
Coordinates 160998..161288 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A217EYW7
Locus tag A9D14_RS18345 Protein ID WP_066850846.1
Coordinates 161281..161535 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D14_RS18325 157104..158387 - 1284 WP_066842647.1 IS256 family transposase -
A9D14_RS18330 158594..159688 - 1095 WP_157668312.1 hypothetical protein -
A9D14_RS18335 160223..160852 - 630 WP_066850844.1 plasmid pRiA4b ORF-3 family protein -
A9D14_RS18340 160998..161288 - 291 WP_066850845.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9D14_RS18345 161281..161535 - 255 WP_066850846.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
A9D14_RS18350 161756..162571 + 816 WP_157668313.1 hypothetical protein -
A9D14_RS18355 162989..163354 + 366 WP_062068004.1 transposase -
A9D14_RS18360 163351..163692 + 342 WP_062068002.1 IS66 family insertion sequence element accessory protein TnpB -
A9D14_RS18365 163766..165409 + 1644 WP_066850848.1 IS66 family transposase -
A9D14_RS18370 165409..165627 + 219 WP_062067998.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..346204 346204
- inside IScluster/Tn - - 151807..163692 11885


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Antitoxin ParD

(7-77)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10953.51 Da        Isoelectric Point: 8.9716

>T72810 WP_066850845.1 NZ_CP019604:c161288-160998 [Croceicoccus marinus]
MPDLQISRRAASDLAEIADYTIAEFGIEQARKYRDLLQSCFQSLLDNPGLGRSAEDLAPGLRRIRQQAHVIFYRPAGSAI
LIVRVLHHNRDFSRYL

Download         Length: 291 bp

>T72810 NZ_CP019604:c161288-160998 [Croceicoccus marinus]
ATGCCTGACCTGCAAATCAGCAGGCGAGCAGCATCCGATCTTGCCGAAATCGCCGATTACACGATAGCTGAGTTTGGCAT
CGAACAGGCCCGCAAGTACCGCGATCTGCTGCAATCCTGTTTTCAATCCCTCCTCGACAACCCGGGTCTCGGCAGAAGCG
CCGAGGACCTTGCGCCCGGTCTGCGCCGGATCAGGCAGCAGGCCCATGTTATCTTTTATCGGCCGGCCGGCAGCGCGATT
CTGATTGTCCGGGTTCTCCACCACAACAGGGACTTCAGCCGATATCTGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9250.15 Da        Isoelectric Point: 4.3055

>AT72810 WP_066850846.1 NZ_CP019604:c161535-161281 [Croceicoccus marinus]
MATIRKTITLSDSQDAWIKAQIARGAFTNDSEYIRDLVRRDQEGQNSLAELRQAIAEGLESGVSDLSLDDIWTTAEKHSP
SADA

Download         Length: 255 bp

>AT72810 NZ_CP019604:c161535-161281 [Croceicoccus marinus]
ATGGCAACCATCCGCAAAACCATCACGCTCAGCGACAGTCAGGATGCCTGGATCAAGGCTCAGATCGCACGCGGGGCATT
CACGAACGACAGCGAATATATTCGTGATCTCGTACGCCGCGATCAGGAAGGGCAGAACAGCTTGGCCGAACTGAGGCAGG
CGATCGCGGAAGGGCTGGAAAGCGGCGTGAGCGATCTGTCGCTGGACGATATATGGACAACAGCAGAGAAACATAGTCCC
TCTGCAGATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A217EYW6

Antitoxin

Source ID Structure
AlphaFold DB A0A217EYW7

References