Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 932762..933238 Replicon chromosome
Accession NZ_CP019595
Organism Staphylococcus aureus strain GD1677

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag BZK09_RS04740 Protein ID WP_000052076.1
Coordinates 932762..932950 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BZK09_RS04745 Protein ID WP_001059690.1
Coordinates 932978..933238 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZK09_RS04710 928792..929274 + 483 WP_031886402.1 hypothetical protein -
BZK09_RS04715 929614..930300 + 687 WP_001574556.1 thermonuclease family protein -
BZK09_RS04720 930657..930857 + 201 WP_001059082.1 cold-shock protein -
BZK09_RS04725 931354..931572 - 219 WP_000005881.1 hypothetical protein -
BZK09_RS04730 931633..931917 - 285 WP_001004403.1 hypothetical protein -
BZK09_RS04735 932005..932574 - 570 WP_001106655.1 hypothetical protein -
BZK09_RS04740 932762..932950 - 189 WP_000052076.1 hypothetical protein Toxin
BZK09_RS04745 932978..933238 - 261 WP_001059690.1 hypothetical protein Antitoxin
BZK09_RS04750 933580..933783 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BZK09_RS04755 933780..934016 - 237 WP_000368687.1 hypothetical protein -
BZK09_RS04760 934241..934822 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
BZK09_RS04765 934895..935512 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
BZK09_RS04770 935661..936155 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
BZK09_RS04775 936554..936976 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
BZK09_RS04780 937124..937840 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T72797 WP_000052076.1 NZ_CP019595:c932950-932762 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T72797 NZ_CP019595:c932950-932762 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT72797 WP_001059690.1 NZ_CP019595:c933238-932978 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT72797 NZ_CP019595:c933238-932978 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References