Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2129984..2130498 Replicon chromosome
Accession NZ_CP019594
Organism Staphylococcus aureus strain GD1539

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag BZK08_RS11000 Protein ID WP_000581792.1
Coordinates 2129984..2130193 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag BZK08_RS11005 Protein ID WP_000138932.1
Coordinates 2130205..2130498 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZK08_RS10980 2125495..2126850 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
BZK08_RS10985 2126865..2127935 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
BZK08_RS10990 2128253..2129455 + 1203 WP_001109939.1 rod shape-determining protein RodA -
BZK08_RS10995 2129719..2129856 - 138 WP_000828354.1 hypothetical protein -
BZK08_RS11000 2129984..2130193 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
BZK08_RS11005 2130205..2130498 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
BZK08_RS11010 2130664..2132148 + 1485 WP_000571550.1 cardiolipin synthase -
BZK08_RS11015 2132176..2132823 + 648 WP_001187614.1 HD domain-containing protein -
BZK08_RS11020 2133103..2133423 + 321 WP_001825748.1 hypothetical protein -
BZK08_RS11025 2133420..2134735 - 1316 Protein_2042 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T72788 WP_000581792.1 NZ_CP019594:c2130193-2129984 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T72788 NZ_CP019594:c2130193-2129984 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT72788 WP_000138932.1 NZ_CP019594:c2130498-2130205 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT72788 NZ_CP019594:c2130498-2130205 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References