72780

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 811191..811667 Replicon chromosome
Accession NZ_CP019594
Organism Staphylococcus aureus strain GD1539

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag BZK08_RS03965 Protein ID WP_000052076.1
Coordinates 811191..811379 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BZK08_RS03970 Protein ID WP_001059690.1
Coordinates 811407..811667 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZK08_RS03935 807220..807702 + 483 WP_000824489.1 hypothetical protein -
BZK08_RS03940 808043..808729 + 687 WP_001574556.1 thermonuclease family protein -
BZK08_RS03945 809086..809286 + 201 WP_001059082.1 cold-shock protein -
BZK08_RS03950 809783..810001 - 219 WP_000005881.1 hypothetical protein -
BZK08_RS03955 810062..810346 - 285 WP_001004403.1 hypothetical protein -
BZK08_RS03960 810434..811003 - 570 WP_001106655.1 hypothetical protein -
BZK08_RS03965 811191..811379 - 189 WP_000052076.1 hypothetical protein Toxin
BZK08_RS03970 811407..811667 - 261 WP_001059690.1 hypothetical protein Antitoxin
BZK08_RS03975 812009..812212 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BZK08_RS03980 812209..812445 - 237 WP_000368687.1 hypothetical protein -
BZK08_RS03985 812670..813251 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
BZK08_RS03990 813324..813941 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
BZK08_RS03995 814090..814584 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
BZK08_RS04000 814983..815405 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
BZK08_RS04005 815553..816269 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T72780 WP_000052076.1 NZ_CP019594:c811379-811191 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T72780 NZ_CP019594:c811379-811191 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT72780 WP_001059690.1 NZ_CP019594:c811667-811407 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT72780 NZ_CP019594:c811667-811407 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References