Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1525749..1526546 Replicon chromosome
Accession NZ_CP019593
Organism Staphylococcus aureus strain GD705

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag BZK07_RS07565 Protein ID WP_084570112.1
Coordinates 1526085..1526546 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag BZK07_RS07560 Protein ID WP_001260486.1
Coordinates 1525749..1526072 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZK07_RS07500 1521022..1521579 - 558 WP_000645045.1 DUF2815 family protein -
BZK07_RS07505 1521605..1522771 - 1167 WP_084570109.1 DUF2800 domain-containing protein -
BZK07_RS07510 1522768..1523130 - 363 WP_084570110.1 hypothetical protein -
BZK07_RS07515 1523145..1523468 - 324 WP_000174996.1 hypothetical protein -
BZK07_RS07520 1523547..1523708 - 162 WP_084570111.1 DUF1270 family protein -
BZK07_RS07525 1523721..1523984 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
BZK07_RS07530 1524039..1524248 + 210 WP_000642492.1 hypothetical protein -
BZK07_RS07535 1524238..1524381 - 144 WP_000939498.1 hypothetical protein -
BZK07_RS07540 1524472..1524687 - 216 WP_001097552.1 hypothetical protein -
BZK07_RS07545 1524742..1525107 + 366 WP_001128433.1 hypothetical protein -
BZK07_RS07550 1525076..1525321 - 246 WP_001025401.1 DUF2829 domain-containing protein -
BZK07_RS07555 1525337..1525585 - 249 WP_031887139.1 helix-turn-helix domain-containing protein -
BZK07_RS07560 1525749..1526072 + 324 WP_001260486.1 helix-turn-helix domain-containing protein Antitoxin
BZK07_RS07565 1526085..1526546 + 462 WP_084570112.1 toxin Toxin
BZK07_RS07570 1526564..1526998 + 435 WP_000755718.1 hypothetical protein -
BZK07_RS07575 1527027..1527422 + 396 WP_084570113.1 hypothetical protein -
BZK07_RS07580 1527512..1527658 + 147 WP_001013104.1 hypothetical protein -
BZK07_RS07585 1527655..1528269 - 615 WP_084570114.1 ATPase -
BZK07_RS07590 1528395..1529600 + 1206 WP_020444721.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17932.22 Da        Isoelectric Point: 4.7787

>T72768 WP_084570112.1 NZ_CP019593:1526085-1526546 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSVFNNRKFENYAR
RHGFTSAVPLHEIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T72768 NZ_CP019593:1526085-1526546 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCTGTTTTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACATGGTTTTACTTCAGCTGTACCGCTACATGAAATTGTAGAAGCTCACAACTACGGTGTTCGTAATTTGTACGAGTT
GTCAGAGTATCTGCAGTTGAGTGAATCATACATACTAGAAGCTATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12427.10 Da        Isoelectric Point: 9.3811

>AT72768 WP_001260486.1 NZ_CP019593:1525749-1526072 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT72768 NZ_CP019593:1525749-1526072 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCTGATTATATAAGAAGCAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References