72763

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 813239..813715 Replicon chromosome
Accession NZ_CP019593
Organism Staphylococcus aureus strain GD705

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag BZK07_RS03980 Protein ID WP_000052076.1
Coordinates 813239..813427 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BZK07_RS03985 Protein ID WP_001059690.1
Coordinates 813455..813715 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZK07_RS03950 809268..809750 + 483 WP_000824489.1 hypothetical protein -
BZK07_RS03955 810091..810777 + 687 WP_001574556.1 thermonuclease family protein -
BZK07_RS03960 811134..811334 + 201 WP_001059082.1 cold-shock protein -
BZK07_RS03965 811831..812049 - 219 WP_000005881.1 hypothetical protein -
BZK07_RS03970 812110..812394 - 285 WP_001004403.1 hypothetical protein -
BZK07_RS03975 812482..813051 - 570 WP_001106655.1 hypothetical protein -
BZK07_RS03980 813239..813427 - 189 WP_000052076.1 hypothetical protein Toxin
BZK07_RS03985 813455..813715 - 261 WP_001059690.1 hypothetical protein Antitoxin
BZK07_RS03990 814057..814260 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BZK07_RS03995 814257..814493 - 237 WP_000368687.1 hypothetical protein -
BZK07_RS04000 814718..815299 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
BZK07_RS04005 815372..815989 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
BZK07_RS04010 816138..816632 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
BZK07_RS04015 817031..817453 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
BZK07_RS04020 817601..818317 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T72763 WP_000052076.1 NZ_CP019593:c813427-813239 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T72763 NZ_CP019593:c813427-813239 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT72763 WP_001059690.1 NZ_CP019593:c813715-813455 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT72763 NZ_CP019593:c813715-813455 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References