Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2120607..2121121 Replicon chromosome
Accession NZ_CP019592
Organism Staphylococcus aureus strain GD5

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag BZJ79_RS10815 Protein ID WP_000581792.1
Coordinates 2120607..2120816 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag BZJ79_RS10820 Protein ID WP_000138932.1
Coordinates 2120828..2121121 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZJ79_RS10795 2116118..2117473 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
BZJ79_RS10800 2117488..2118558 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
BZJ79_RS10805 2118876..2120078 + 1203 WP_001109939.1 rod shape-determining protein RodA -
BZJ79_RS10810 2120342..2120479 - 138 WP_000828354.1 hypothetical protein -
BZJ79_RS10815 2120607..2120816 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
BZJ79_RS10820 2120828..2121121 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
BZJ79_RS10825 2121287..2122771 + 1485 WP_000571550.1 cardiolipin synthase -
BZJ79_RS10830 2122799..2123446 + 648 WP_001187614.1 HD domain-containing protein -
BZJ79_RS10840 2123726..2124046 + 321 WP_001825748.1 hypothetical protein -
BZJ79_RS10845 2124043..2125358 - 1316 Protein_1984 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T72758 WP_000581792.1 NZ_CP019592:c2120816-2120607 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T72758 NZ_CP019592:c2120816-2120607 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT72758 WP_000138932.1 NZ_CP019592:c2121121-2120828 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT72758 NZ_CP019592:c2121121-2120828 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References