72750

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 868886..869362 Replicon chromosome
Accession NZ_CP019592
Organism Staphylococcus aureus strain GD5

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag BZJ79_RS04295 Protein ID WP_000052076.1
Coordinates 868886..869074 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BZJ79_RS04300 Protein ID WP_001059690.1
Coordinates 869102..869362 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZJ79_RS04265 864915..865397 + 483 WP_000824489.1 hypothetical protein -
BZJ79_RS04270 865738..866424 + 687 WP_001574556.1 thermonuclease family protein -
BZJ79_RS04275 866781..866981 + 201 WP_001059082.1 cold-shock protein -
BZJ79_RS04280 867478..867696 - 219 WP_000005881.1 hypothetical protein -
BZJ79_RS04285 867757..868041 - 285 WP_001004403.1 hypothetical protein -
BZJ79_RS04290 868129..868698 - 570 WP_001106655.1 hypothetical protein -
BZJ79_RS04295 868886..869074 - 189 WP_000052076.1 hypothetical protein Toxin
BZJ79_RS04300 869102..869362 - 261 WP_001059690.1 hypothetical protein Antitoxin
BZJ79_RS04305 869704..869907 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BZJ79_RS04310 869904..870140 - 237 WP_000368687.1 hypothetical protein -
BZJ79_RS04315 870365..870946 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
BZJ79_RS04320 871019..871636 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
BZJ79_RS04325 871785..872279 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
BZJ79_RS04330 872667..873089 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
BZJ79_RS04335 873237..873953 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T72750 WP_000052076.1 NZ_CP019592:c869074-868886 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T72750 NZ_CP019592:c869074-868886 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT72750 WP_001059690.1 NZ_CP019592:c869362-869102 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT72750 NZ_CP019592:c869362-869102 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References