Detailed information of TA system TA072738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 814007..814483
• Replicon: chromosome
• Accession: NZ_CP019591
• Organism: Staphylococcus aureus strain 293G

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: BXP64_RS03990
• Protein ID: WP_000052076.1
• Coordinates: 814007..814195 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: BXP64_RS03995
• Protein ID: WP_113624607.1
• Coordinates: 814223..814483 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BXP64_RS03960	810036..810518	+	483	WP_000824490.1	hypothetical protein	-
BXP64_RS03965	810859..811545	+	687	WP_001574556.1	thermonuclease family protein	-
BXP64_RS03970	811902..812102	+	201	WP_001059082.1	cold-shock protein	-
BXP64_RS03975	812599..812817	-	219	WP_000005881.1	hypothetical protein	-
BXP64_RS03980	812878..813162	-	285	WP_001004403.1	hypothetical protein	-
BXP64_RS03985	813250..813819	-	570	WP_001106655.1	hypothetical protein	-
BXP64_RS03990	814007..814195	-	189	WP_000052076.1	hypothetical protein	Toxin
BXP64_RS03995	814223..814483	-	261	WP_113624607.1	hypothetical protein	Antitoxin
BXP64_RS04000	814825..815028	+	204	WP_000145166.1	sterile alpha motif-like domain-containing protein	-
BXP64_RS04005	815025..815261	-	237	WP_000368687.1	hypothetical protein	-
BXP64_RS04010	815486..816067	+	582	WP_001140696.1	phosphoglycerate mutase family protein	-
BXP64_RS04015	816140..816757	-	618	WP_000255562.1	LysE/ArgO family amino acid transporter	-
BXP64_RS04020	816906..817400	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
BXP64_RS04025	817799..818221	-	423	WP_000974452.1	organic hydroperoxide resistance protein	-
BXP64_RS04030	818369..819085	+	717	WP_000150026.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-93)

Antitoxin

• Antitoxin ParD (2-80)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T72738 WP_000052076.1 NZ_CP019591:c814195-814007 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T72738 NZ_CP019591:c814195-814007 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9989.16 Da
• Isoelectric Point: 4.0624

>AT72738 WP_113624607.1 NZ_CP019591:c814483-814223 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFYILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT72738 NZ_CP019591:c814483-814223 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTTATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18