Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2214081..2214595 Replicon chromosome
Accession NZ_CP019590
Organism Staphylococcus aureus strain C2406

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag BJN19_RS11615 Protein ID WP_000581792.1
Coordinates 2214081..2214290 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag BJN19_RS11620 Protein ID WP_000138932.1
Coordinates 2214302..2214595 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJN19_RS11595 2209589..2210947 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
BJN19_RS11600 2210962..2212032 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
BJN19_RS11605 2212350..2213552 + 1203 WP_001109939.1 rod shape-determining protein RodA -
BJN19_RS11610 2213816..2213953 - 138 WP_000828354.1 hypothetical protein -
BJN19_RS11615 2214081..2214290 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
BJN19_RS11620 2214302..2214595 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
BJN19_RS11625 2214761..2216245 + 1485 WP_000571549.1 cardiolipin synthase -
BJN19_RS11630 2216273..2216920 + 648 WP_001187629.1 HD domain-containing protein -
BJN19_RS11650 2217733..2218605 - 873 WP_000725802.1 membrane protein insertase YidC -
BJN19_RS11655 2218691..2219332 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T72731 WP_000581792.1 NZ_CP019590:c2214290-2214081 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T72731 NZ_CP019590:c2214290-2214081 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT72731 WP_000138932.1 NZ_CP019590:c2214595-2214302 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT72731 NZ_CP019590:c2214595-2214302 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References