Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 889223..889700 Replicon chromosome
Accession NZ_CP019590
Organism Staphylococcus aureus strain C2406

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag BJN19_RS04510 Protein ID WP_000052078.1
Coordinates 889223..889411 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BJN19_RS04515 Protein ID WP_001059690.1
Coordinates 889440..889700 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJN19_RS04480 885264..885734 + 471 WP_000824472.1 hypothetical protein -
BJN19_RS04485 886075..886761 + 687 WP_001548082.1 thermonuclease family protein -
BJN19_RS04490 887118..887318 + 201 WP_001059082.1 cold-shock protein -
BJN19_RS04495 887814..888032 - 219 WP_000005886.1 hypothetical protein -
BJN19_RS04500 888094..888378 - 285 WP_001004395.1 hypothetical protein -
BJN19_RS04505 888466..889035 - 570 WP_001106654.1 hypothetical protein -
BJN19_RS04510 889223..889411 - 189 WP_000052078.1 hypothetical protein Toxin
BJN19_RS04515 889440..889700 - 261 WP_001059690.1 hypothetical protein Antitoxin
BJN19_RS04520 890041..890244 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BJN19_RS04525 890241..890477 - 237 WP_000368687.1 hypothetical protein -
BJN19_RS04530 890702..891283 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
BJN19_RS04535 891356..891973 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
BJN19_RS04540 892128..892622 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
BJN19_RS04545 893021..893443 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
BJN19_RS04550 893591..894307 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 885264..914989 29725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T72722 WP_000052078.1 NZ_CP019590:c889411-889223 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T72722 NZ_CP019590:c889411-889223 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT72722 WP_001059690.1 NZ_CP019590:c889700-889440 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT72722 NZ_CP019590:c889700-889440 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References