Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 241201..241843 Replicon chromosome
Accession NZ_CP019588
Organism Bacillus anthracis strain SPV842_15

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag BZG08_RS01390 Protein ID WP_000635963.1
Coordinates 241493..241843 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag BZG08_RS01385 Protein ID WP_000004570.1
Coordinates 241201..241488 (+) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZG08_RS01360 236517..237479 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
BZG08_RS01365 237472..238044 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
BZG08_RS01370 238137..238496 + 360 WP_000635040.1 holo-ACP synthase -
BZG08_RS01375 238653..239603 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
BZG08_RS01380 239722..240891 + 1170 WP_000390596.1 alanine racemase -
BZG08_RS01385 241201..241488 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
BZG08_RS01390 241493..241843 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BZG08_RS01395 241911..244079 + 2169 WP_000426225.1 RNA-binding transcriptional accessory protein -
BZG08_RS01400 244137..244253 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
BZG08_RS01405 244449..244907 + 459 WP_000344248.1 SprT family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-113)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T72720 WP_000635963.1 NZ_CP019588:241493-241843 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T72720 NZ_CP019588:241493-241843 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT72720 WP_000004570.1 NZ_CP019588:241201-241488 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT72720 NZ_CP019588:241201-241488 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY


Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References