Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 177885..178483 Replicon plasmid pSymA
Accession NZ_CP019585
Organism Sinorhizobium meliloti strain CCMM B554 (FSM-MA)

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag SMB554_RS18860 Protein ID WP_088895903.1
Coordinates 178190..178483 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag SMB554_RS18855 Protein ID WP_088895902.1
Coordinates 177885..178190 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMB554_RS18830 173394..174944 - 1551 WP_088895899.1 calcium-binding protein -
SMB554_RS18835 175489..175752 - 264 Protein_172 DUF2798 domain-containing protein -
SMB554_RS18840 175755..176681 - 927 WP_198389636.1 NmrA/HSCARG family protein -
SMB554_RS18845 176764..177657 + 894 WP_198389637.1 LysR family transcriptional regulator -
SMB554_RS18855 177885..178190 + 306 WP_088895902.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SMB554_RS18860 178190..178483 + 294 WP_088895903.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMB554_RS18865 178801..180213 - 1413 WP_088895904.1 PhoPQ-activated pathogenicity-related family protein -
SMB554_RS18870 180920..181198 - 279 WP_088895905.1 hypothetical protein -
SMB554_RS18875 181375..181647 - 273 WP_088895906.1 DUF2934 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB / htpB 1..1422736 1422736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10978.52 Da        Isoelectric Point: 4.8780

>T72713 WP_088895903.1 NZ_CP019585:178190-178483 [Sinorhizobium meliloti]
MRLVWARYALDDRDTIFSCIERENPGAAVHADEEIVSAVRRLLDFPESGRPGRVAGTRELVIPRTPYIAACMVMADTVRI
LRDLHGAQKWPSELDDE

Download         Length: 294 bp

>T72713 NZ_CP019585:178190-178483 [Sinorhizobium meliloti]
ATGAGGCTCGTCTGGGCGCGATATGCGCTGGACGATCGCGACACCATCTTCAGTTGCATCGAAAGGGAGAATCCGGGGGC
GGCGGTACACGCTGACGAGGAGATCGTCAGCGCGGTACGTCGTCTACTGGATTTTCCGGAAAGCGGCCGCCCTGGCCGGG
TTGCCGGAACTCGAGAGCTTGTTATCCCTCGGACTCCCTACATTGCAGCCTGCATGGTAATGGCGGATACAGTTCGAATT
CTGCGTGACCTGCATGGCGCCCAGAAGTGGCCCAGCGAGCTCGACGACGAGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11096.47 Da        Isoelectric Point: 5.1884

>AT72713 WP_088895902.1 NZ_CP019585:177885-178190 [Sinorhizobium meliloti]
MASNALVQTRIDAEVKERATAVLENMGLTVSDAVRILLTRTANEGALPLELFSHSEVHDAWFRAKVLRALEDTRPDVDDA
DAEAHFRERRAAALRKAAAGD

Download         Length: 306 bp

>AT72713 NZ_CP019585:177885-178190 [Sinorhizobium meliloti]
ATGGCTTCAAATGCACTTGTTCAGACTCGGATCGATGCCGAGGTCAAAGAGCGCGCCACGGCGGTTTTAGAGAACATGGG
TCTGACGGTCTCGGATGCTGTTCGAATCCTGTTAACTCGGACGGCGAATGAGGGCGCTCTGCCGCTGGAACTCTTCAGTC
ACAGCGAGGTGCACGACGCTTGGTTCCGCGCCAAAGTGTTGCGGGCACTCGAGGATACCCGACCCGACGTCGACGATGCC
GATGCCGAGGCGCACTTTCGAGAGCGCCGGGCGGCAGCTTTGCGCAAGGCTGCGGCGGGTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References