Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2163209..2163723 Replicon chromosome
Accession NZ_CP019574
Organism Staphylococcus aureus strain USA400-0051

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag SAU400_RS11230 Protein ID WP_000581793.1
Coordinates 2163209..2163418 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag SAU400_RS11235 Protein ID WP_000138932.1
Coordinates 2163430..2163723 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAU400_RS11210 2158718..2160076 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SAU400_RS11215 2160091..2161161 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
SAU400_RS11220 2161479..2162681 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SAU400_RS11225 2162944..2163081 - 138 WP_000828354.1 hypothetical protein -
SAU400_RS11230 2163209..2163418 - 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
SAU400_RS11235 2163430..2163723 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAU400_RS11240 2163889..2165373 + 1485 WP_000571549.1 cardiolipin synthase -
SAU400_RS11245 2165401..2166048 + 648 WP_001187628.1 HD domain-containing protein -
SAU400_RS11260 2166662..2167534 - 873 WP_000725802.1 membrane protein insertase YidC -
SAU400_RS11265 2167620..2168261 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T72695 WP_000581793.1 NZ_CP019574:c2163418-2163209 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T72695 NZ_CP019574:c2163418-2163209 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT72695 WP_000138932.1 NZ_CP019574:c2163723-2163430 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT72695 NZ_CP019574:c2163723-2163430 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References