Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2737144..2737658 Replicon chromosome
Accession NZ_CP019563
Organism Staphylococcus aureus strain SR434

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag BZP34_RS14310 Protein ID WP_000581792.1
Coordinates 2737449..2737658 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag BZP34_RS14305 Protein ID WP_000138932.1
Coordinates 2737144..2737437 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZP34_RS14280 2732760..2733401 + 642 WP_000483153.1 thiamine phosphate synthase -
BZP34_RS14285 2733487..2734353 + 867 WP_064139140.1 membrane protein insertase YidC -
BZP34_RS14295 2734819..2735466 - 648 WP_001187630.1 HD domain-containing protein -
BZP34_RS14300 2735494..2736978 - 1485 WP_000571549.1 cardiolipin synthase -
BZP34_RS14305 2737144..2737437 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
BZP34_RS14310 2737449..2737658 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
BZP34_RS14315 2737786..2737923 + 138 WP_000828354.1 hypothetical protein -
BZP34_RS14320 2738187..2739389 - 1203 WP_001109936.1 rod shape-determining protein RodA -
BZP34_RS14325 2739707..2740777 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
BZP34_RS14330 2740792..2742150 + 1359 WP_000611459.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T72676 WP_000581792.1 NZ_CP019563:2737449-2737658 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T72676 NZ_CP019563:2737449-2737658 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT72676 WP_000138932.1 NZ_CP019563:2737144-2737437 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT72676 NZ_CP019563:2737144-2737437 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References