Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1190395..1190872 Replicon chromosome
Accession NZ_CP019563
Organism Staphylococcus aureus strain SR434

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag BZP34_RS06260 Protein ID WP_000052076.1
Coordinates 1190684..1190872 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BZP34_RS06255 Protein ID WP_001059690.1
Coordinates 1190395..1190655 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZP34_RS06220 1185788..1186504 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
BZP34_RS06225 1186652..1187074 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
BZP34_RS06230 1187473..1187967 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
BZP34_RS06235 1188122..1188739 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
BZP34_RS06240 1188812..1189393 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
BZP34_RS06245 1189618..1189854 + 237 WP_000349581.1 hypothetical protein -
BZP34_RS06250 1189851..1190054 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BZP34_RS06255 1190395..1190655 + 261 WP_001059690.1 hypothetical protein Antitoxin
BZP34_RS06260 1190684..1190872 + 189 WP_000052076.1 hypothetical protein Toxin
BZP34_RS06265 1191060..1191629 + 570 WP_001106654.1 hypothetical protein -
BZP34_RS06270 1191717..1192001 + 285 WP_001004399.1 hypothetical protein -
BZP34_RS06275 1192063..1192281 + 219 WP_000005886.1 hypothetical protein -
BZP34_RS06280 1192773..1192973 - 201 WP_001059082.1 cold-shock protein -
BZP34_RS06285 1193330..1194016 - 687 WP_000141557.1 thermonuclease family protein -
BZP34_RS06290 1194357..1194878 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T72667 WP_000052076.1 NZ_CP019563:1190684-1190872 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T72667 NZ_CP019563:1190684-1190872 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT72667 WP_001059690.1 NZ_CP019563:1190395-1190655 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT72667 NZ_CP019563:1190395-1190655 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References