Detailed information of TA system TA072666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 160163..160936
• Replicon: chromosome
• Accession: NZ_CP019563
• Organism: Staphylococcus aureus strain SR434

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: BZP34_RS01070
• Protein ID: WP_000031107.1
• Coordinates: 160787..160936 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: BZP34_RS01065
• Protein ID: WP_001251224.1
• Coordinates: 160163..160762 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZP34_RS01045	156079..157536	+	1458	WP_000649908.1	ABC transporter permease subunit	-
BZP34_RS01050	157529..158251	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
BZP34_RS01055	158402..159529	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
BZP34_RS01060	159534..160004	+	471	WP_000181392.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
BZP34_RS01065	160163..160762	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
BZP34_RS01070	160787..160936	+	150	WP_000031107.1	hypothetical protein	Toxin
BZP34_RS01075	161487..161882	+	396	WP_000901023.1	hypothetical protein	-
BZP34_RS01080	162078..163463	+	1386	WP_000116234.1	class II fumarate hydratase	-
BZP34_RS01085	163926..164747	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5808.15 Da
• Isoelectric Point: 3.8962

>T72666 WP_000031107.1 NZ_CP019563:160787-160936 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDS

Nucleotide

• Length: 150 bp

>T72666 NZ_CP019563:160787-160936 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT72666 WP_001251224.1 NZ_CP019563:160163-160762 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT72666 NZ_CP019563:160163-160762 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4