Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 1192257..1193503 Replicon chromosome
Accession NZ_CP019562
Organism Streptococcus oralis strain S.MIT/ORALIS-351

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag BWR56_RS05810 Protein ID WP_076984625.1
Coordinates 1192257..1193027 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag BWR56_RS05815 Protein ID WP_076984626.1
Coordinates 1193027..1193503 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWR56_RS05795 1187407..1189686 + 2280 WP_076984622.1 ATP-binding protein -
BWR56_RS05800 1189670..1190911 - 1242 WP_076984623.1 glycine hydroxymethyltransferase -
BWR56_RS05805 1191002..1191898 + 897 WP_076984624.1 tyrosine-type recombinase/integrase -
BWR56_RS05810 1192257..1193027 - 771 WP_076984625.1 zeta toxin family protein Toxin
BWR56_RS05815 1193027..1193503 - 477 WP_076984626.1 helix-turn-helix domain-containing protein Antitoxin
BWR56_RS05820 1193658..1193885 - 228 WP_076984627.1 hypothetical protein -
BWR56_RS05825 1194108..1195292 - 1185 WP_076984628.1 hypothetical protein -
BWR56_RS05830 1195296..1195883 - 588 WP_076984629.1 ABC transporter ATP-binding protein -
BWR56_RS05835 1195915..1196178 - 264 WP_076984630.1 hypothetical protein -
BWR56_RS05840 1196516..1197040 - 525 Protein_1134 DUF3990 domain-containing protein -
BWR56_RS05845 1197046..1197321 - 276 WP_076984631.1 hypothetical protein -
BWR56_RS05850 1197359..1197742 - 384 WP_076984632.1 chemotaxis protein -
BWR56_RS05855 1197739..1197972 - 234 WP_076984633.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1130468..1222523 92055


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29362.41 Da        Isoelectric Point: 7.5072

>T72662 WP_076984625.1 NZ_CP019562:c1193027-1192257 [Streptococcus oralis]
MEIQDYTDSEFKQALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDSTRQLEELAIFEKIQIYQRDRSCVYDSKENTTSAATVLHDLLFVEWNQVEKEML
KFGEERLKDLTNRNGC

Download         Length: 771 bp

>T72662 NZ_CP019562:c1193027-1192257 [Streptococcus oralis]
ATGGAAATCCAAGATTATACCGATAGTGAATTCAAACAGGCTTTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAGCCTATAGCGATTTTGCTTGGGGGACAAAGTGGTGCTGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCCCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTAGTAACCGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACAATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGCTATCCTATCTGAGTACCCTTATCCGATATGAAGAA
CTGTACGCTATTAATCCAAATCAAGCTCGCGCAACACCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAG
TACACGGCAATTGGAAGAACTAGCTATCTTTGAAAAAATCCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACATCAGCAGCAACCGTTCTTCATGATTTACTATTTGTAGAATGGAATCAAGTTGAGAAAGAGATGCTT
AAATTTGGAGAAGAAAGATTGAAAGATTTAACTAATCGAAATGGTTGTTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18247.70 Da        Isoelectric Point: 4.4119

>AT72662 WP_076984626.1 NZ_CP019562:c1193503-1193027 [Streptococcus oralis]
MIGKNIKSLRKTHDLTQLEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVDTFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT72662 NZ_CP019562:c1193503-1193027 [Streptococcus oralis]
ATGATTGGAAAGAACATAAAATCCCTACGTAAAACACATGACTTAACACAACTCGAATTTGCCCGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGCACTAGTTCAGTTTCTACGGAACTAATAGACATCATCTGCCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTACTATCTCGACTCTATCGTTATCAAGATAGCCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTGGATACTTTTGATG
AAATAGAGAGATATAGCGGTTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References