Detailed information of TA system TA072626

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 720934..721416
• Replicon: chromosome
• Accession: NZ_CP019557
• Organism: Streptococcus sp. DAT741

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BZG42_RS03500
• Protein ID: WP_155962643.1
• Coordinates: 721156..721416 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BZG42_RS03495
• Protein ID: WP_155970830.1
• Coordinates: 720934..721155 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZG42_RS09945	717851..719962	-	2112	WP_201443301.1	YSIRK-type signal peptide-containing protein	-
BZG42_RS03490	720405..720734	+	330	WP_024532382.1	hypothetical protein	-
BZG42_RS03495	720934..721155	+	222	WP_155970830.1	translation repressor RelB	Antitoxin
BZG42_RS03500	721156..721416	+	261	WP_155962643.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BZG42_RS03505	721385..721711	+	327	WP_155995651.1	hypothetical protein	-
BZG42_RS03510	721983..722945	-	963	WP_155970832.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
BZG42_RS03515	723145..725304	-	2160	WP_120171507.1	class 1b ribonucleoside-diphosphate reductase subunit alpha	-
BZG42_RS03520	725347..725565	-	219	WP_024532387.1	glutaredoxin-like protein NrdH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	720405..725565	5160

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10264.78 Da
• Isoelectric Point: 9.6925

>T72626 WP_155962643.1 NZ_CP019557:721156-721416 [Streptococcus sp. DAT741]
MYHVEYSKKAQKQIRKLDKSIQRLLFAWVDKHLDGTDTPRTNGKGLTGNHANEWRYRIGDYRLICEIQEDKMVILALEFG
HRKDIY

Nucleotide

• Length: 261 bp

>T72626 NZ_CP019557:721156-721416 [Streptococcus sp. DAT741]
ATGTATCATGTAGAGTATTCAAAAAAGGCTCAAAAGCAGATCAGAAAGCTGGATAAATCTATCCAAAGGCTACTTTTTGC
TTGGGTAGATAAGCATTTAGACGGTACAGACACCCCACGAACTAACGGCAAGGGATTGACAGGAAACCACGCCAATGAAT
GGCGTTATCGTATCGGTGATTATAGACTGATATGCGAAATTCAAGAGGATAAGATGGTTATTCTAGCTCTTGAGTTTGGG
CATAGGAAAGATATTTACTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8527.60 Da
• Isoelectric Point: 4.6128

>AT72626 WP_155970830.1 NZ_CP019557:720934-721155 [Streptococcus sp. DAT741]
MSTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYKQAYAEYKADPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT72626 NZ_CP019557:720934-721155 [Streptococcus sp. DAT741]
ATGAGTACAGTAACTATCAGATTAAATCAAGAAGAAGAAATATTTTTCAAAAGCTATGCTCAATTAACAGGGCAAAGTCT
TTCAAGTCTTTTCAAGAAAGCTCTTGAGCGTGATATTGAAGATGAGTATGATTTGAAAATTTATAAACAAGCCTATGCTG
AATACAAAGCAGACCCAGAGACAATTAGCCATGCTGATTTTAAGAAAGAGCTGGGCTTGTAA