Detailed information of TA system TA072623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2867397..2867953
• Replicon: chromosome
• Accession: NZ_CP019516
• Organism: Xanthomonas oryzae pv. oryzae strain CR1-5

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BXU04_RS13525
• Protein ID: WP_229001948.1
• Coordinates: 2867397..2867648 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: BXU04_RS13530
• Protein ID: WP_011408759.1
• Coordinates: 2867675..2867953 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BXU04_RS13485 (BXU04_14370)	2863167..2864258	+	1092	WP_041182166.1	ribonuclease D	-
BXU04_RS13490 (BXU04_14375)	2864334..2864671	-	338	Protein_2575	ATP-dependent DNA ligase	-
BXU04_RS13495 (BXU04_14385)	2864953..2865129	-	177	Protein_2576	DUF3606 domain-containing protein	-
BXU04_RS13500 (BXU04_14390)	2865351..2865752	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
BXU04_RS23025	2866183..2866311	-	129	WP_012444694.1	hypothetical protein	-
BXU04_RS13510 (BXU04_14405)	2866280..2866399	-	120	Protein_2579	IS3 family transposase	-
BXU04_RS13515 (BXU04_14410)	2866616..2866870	-	255	WP_223293127.1	hypothetical protein	-
BXU04_RS13520	2866939..2867136	-	198	WP_004541336.1	hypothetical protein	-
BXU04_RS13525 (BXU04_14420)	2867397..2867648	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BXU04_RS13530 (BXU04_14425)	2867675..2867953	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
BXU04_RS13535	2868149..2868493	-	345	WP_199285675.1	hypothetical protein	-
BXU04_RS13540 (BXU04_14435)	2869399..2870583	-	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
BXU04_RS13545 (BXU04_14440)	2871164..2872129	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
BXU04_RS13550 (BXU04_14445)	2872279..2872836	+	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T72623 WP_229001948.1 NZ_CP019516:c2867648-2867397 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T72623 NZ_CP019516:c2867648-2867397 [Xanthomonas oryzae pv. oryzae]
ATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGGGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT72623 WP_011408759.1 NZ_CP019516:c2867953-2867675 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT72623 NZ_CP019516:c2867953-2867675 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2