Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3615613..3616193 Replicon chromosome
Accession NZ_CP019509
Organism Aquaspirillum sp. LM1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BXU06_RS15690 Protein ID WP_150125239.1
Coordinates 3615852..3616193 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BXU06_RS15685 Protein ID WP_077301731.1
Coordinates 3615613..3615855 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BXU06_RS15660 3611417..3612451 - 1035 WP_077301719.1 Rpn family recombination-promoting nuclease/putative transposase -
BXU06_RS15665 3612554..3612880 + 327 WP_077302977.1 type II toxin-antitoxin system RelE/ParE family toxin -
BXU06_RS15670 3612873..3613184 + 312 WP_077301722.1 helix-turn-helix transcriptional regulator -
BXU06_RS15675 3613344..3614342 - 999 WP_077301725.1 Rpn family recombination-promoting nuclease/putative transposase -
BXU06_RS15680 3614363..3615349 - 987 WP_077301728.1 Rpn family recombination-promoting nuclease/putative transposase -
BXU06_RS15685 3615613..3615855 + 243 WP_077301731.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BXU06_RS15690 3615852..3616193 + 342 WP_150125239.1 endoribonuclease MazF Toxin
BXU06_RS17770 3617149..3617733 - 585 WP_171982244.1 hypothetical protein -
BXU06_RS15695 3617734..3619704 + 1971 WP_171982245.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3602467..3637052 34585


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-109)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12309.26 Da        Isoelectric Point: 9.8634

>T72574 WP_150125239.1 NZ_CP019509:3615852-3616193 [Aquaspirillum sp. LM1]
MMAVYVPDEGDIVWLNFTPQSGHEQAGRRPAVVLSPKAYNQRSGLLICVPITNQIKGYPFEVVLGGNGATGAALADQVKN
LDWKSRQAERKGQATPTEMAEIKAKIKVLLKFA

Download         Length: 342 bp

>T72574 NZ_CP019509:3615852-3616193 [Aquaspirillum sp. LM1]
CTGATGGCGGTGTACGTACCGGATGAGGGCGACATTGTCTGGTTGAATTTCACGCCACAGAGCGGACACGAGCAGGCAGG
GCGGCGACCGGCTGTCGTCTTGAGTCCGAAGGCCTACAACCAGCGCTCGGGGCTATTGATCTGCGTGCCGATCACCAACC
AGATCAAGGGTTATCCTTTCGAGGTCGTGCTTGGGGGGAATGGCGCAACCGGTGCAGCACTGGCCGACCAAGTCAAGAAT
CTCGACTGGAAATCCCGGCAAGCTGAACGCAAGGGGCAAGCCACACCGACCGAGATGGCCGAGATCAAGGCGAAGATCAA
GGTGCTGCTCAAATTTGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8718.01 Da        Isoelectric Point: 4.9732

>AT72574 WP_077301731.1 NZ_CP019509:3615613-3615855 [Aquaspirillum sp. LM1]
MALQFVKKWGNSPAVRLPAAIMEAAHLSLDQPVEVRAENGRIVIEPAAPVYSLDDLLAGITAKNRHTEQDFGLPQGQELL

Download         Length: 243 bp

>AT72574 NZ_CP019509:3615613-3615855 [Aquaspirillum sp. LM1]
ATGGCACTTCAATTCGTTAAGAAATGGGGTAACAGTCCCGCAGTGCGTTTGCCGGCCGCCATCATGGAAGCCGCACACCT
CTCGCTTGATCAGCCCGTCGAAGTGCGAGCTGAGAATGGCCGTATCGTCATCGAGCCGGCAGCACCGGTCTACAGCCTGG
ATGATCTGCTGGCCGGCATTACAGCCAAGAACCGGCATACCGAGCAGGACTTTGGGTTGCCACAGGGTCAGGAGTTGCTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References