Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 3556482..3557056 Replicon chromosome
Accession NZ_CP019508
Organism Brevundimonas sp. LM2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BZG35_RS17420 Protein ID WP_077357642.1
Coordinates 3556482..3556847 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BZG35_RS17425 Protein ID WP_077357644.1
Coordinates 3556841..3557056 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZG35_RS17400 3552166..3552573 - 408 WP_077357635.1 GxxExxY protein -
BZG35_RS17405 3552610..3553791 - 1182 WP_077357637.1 aspartate aminotransferase family protein -
BZG35_RS17410 3554027..3554848 - 822 WP_077357639.1 ABC transporter permease -
BZG35_RS17415 3555072..3556469 - 1398 WP_077357641.1 dihydrolipoyl dehydrogenase -
BZG35_RS17420 3556482..3556847 - 366 WP_077357642.1 type II toxin-antitoxin system VapC family toxin Toxin
BZG35_RS17425 3556841..3557056 - 216 WP_077357644.1 ribbon-helix-helix protein, CopG family Antitoxin
BZG35_RS17430 3557117..3558928 - 1812 WP_077357646.1 2-oxo acid dehydrogenase subunit E2 -
BZG35_RS17435 3558928..3559998 - 1071 WP_077358273.1 alpha-ketoacid dehydrogenase subunit beta -
BZG35_RS17440 3560046..3561278 - 1233 WP_077357648.1 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) subunit alpha -
BZG35_RS17445 3561422..3561913 + 492 WP_077357650.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13338.22 Da        Isoelectric Point: 4.5296

>T72568 WP_077357642.1 NZ_CP019508:c3556847-3556482 [Brevundimonas sp. LM2]
MVKALFDTNILIDHLNGAPQADAEIERYQDRAISIITWIEVMAGAEADMAEPTRTYLDGYAIVGLDDRIAEQAVSIRQSR
RLKLPDAIILASAQATARLLVTRNTKDFPADDPGVRAPYVL

Download         Length: 366 bp

>T72568 NZ_CP019508:c3556847-3556482 [Brevundimonas sp. LM2]
ATGGTGAAGGCTCTGTTCGACACCAATATTCTGATCGACCATCTGAACGGAGCGCCGCAGGCCGATGCCGAGATCGAGCG
ATACCAGGATCGCGCAATCAGCATCATCACCTGGATCGAGGTCATGGCGGGGGCCGAAGCCGACATGGCCGAGCCGACCC
GGACCTATCTCGACGGTTATGCCATCGTGGGCCTTGACGACCGGATCGCCGAGCAGGCGGTGTCCATCCGCCAGTCGCGC
CGCCTGAAGCTTCCGGACGCCATCATCCTGGCGTCCGCTCAGGCAACGGCCCGCCTTCTGGTCACCCGAAACACCAAGGA
TTTCCCGGCCGACGATCCGGGAGTCCGAGCCCCCTATGTTCTGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8094.13 Da        Isoelectric Point: 7.0128

>AT72568 WP_077357644.1 NZ_CP019508:c3557056-3556841 [Brevundimonas sp. LM2]
MRILVDANEEQVAALDALAKREKRPRAAVIRAAIDDYVARHQRQAVKDGFGLWGKDGEDGLAYQERLRSEW

Download         Length: 216 bp

>AT72568 NZ_CP019508:c3557056-3556841 [Brevundimonas sp. LM2]
ATGCGGATCCTGGTTGATGCCAATGAGGAGCAGGTCGCGGCGCTGGACGCCCTGGCCAAACGCGAAAAGCGCCCACGCGC
CGCGGTGATCCGCGCCGCGATCGATGATTACGTCGCGCGCCACCAGCGCCAGGCCGTCAAGGATGGGTTCGGCCTTTGGG
GCAAGGATGGTGAAGACGGCCTCGCATATCAGGAGCGGCTGCGCAGCGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References