Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 2565473..2566026 Replicon chromosome
Accession NZ_CP019508
Organism Brevundimonas sp. LM2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BZG35_RS12710 Protein ID WP_077355989.1
Coordinates 2565697..2566026 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BZG35_RS12705 Protein ID WP_077355988.1
Coordinates 2565473..2565700 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZG35_RS12680 2560525..2561040 + 516 WP_077355983.1 hypothetical protein -
BZG35_RS12685 2561041..2561811 - 771 WP_077355984.1 chorismate mutase -
BZG35_RS12690 2562085..2562666 - 582 WP_077355985.1 prephenate dehydratase -
BZG35_RS12695 2562794..2564023 + 1230 WP_077355986.1 FAD-dependent oxidoreductase -
BZG35_RS12700 2564027..2565397 - 1371 WP_077355987.1 3-deoxy-7-phosphoheptulonate synthase class II -
BZG35_RS12705 2565473..2565700 + 228 WP_077355988.1 DUF433 domain-containing protein Antitoxin
BZG35_RS12710 2565697..2566026 + 330 WP_077355989.1 DUF5615 family PIN-like protein Toxin
BZG35_RS12715 2566031..2567425 - 1395 WP_077355990.1 glutathione-disulfide reductase -
BZG35_RS12720 2567571..2568254 - 684 WP_077355991.1 ribose-5-phosphate isomerase RpiA -
BZG35_RS12725 2568453..2569805 - 1353 WP_077355992.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
BZG35_RS12730 2569875..2570591 + 717 WP_077355993.1 HAD-IA family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2554677..2566026 11349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(2-77)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12283.11 Da        Isoelectric Point: 7.2058

>T72567 WP_077355989.1 NZ_CP019508:2565697-2566026 [Brevundimonas sp. LM2]
VRFVVDANLPPDIADWLRSRGHDAVAVRDLGLRESPDGPIWDAALARGAVVITKDADFAMWALSRDPAPRIVWLRTGNLR
RRAQLEHLDKVWLSVLNRLANDAPIVEVW

Download         Length: 330 bp

>T72567 NZ_CP019508:2565697-2566026 [Brevundimonas sp. LM2]
GTGAGGTTTGTCGTCGATGCCAATCTGCCTCCGGACATAGCCGACTGGCTGAGATCGCGCGGACACGATGCGGTCGCCGT
AAGGGACCTCGGTCTACGCGAAAGCCCGGACGGTCCGATTTGGGATGCCGCCCTCGCAAGGGGCGCCGTCGTCATCACGA
AAGACGCCGACTTCGCCATGTGGGCCTTGTCCAGAGACCCAGCCCCGAGGATCGTCTGGCTGCGCACCGGCAACTTGAGA
CGACGCGCGCAGCTGGAGCATCTGGATAAGGTCTGGCTGAGCGTCCTGAACCGCCTCGCCAACGACGCCCCCATCGTCGA
GGTTTGGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8382.63 Da        Isoelectric Point: 4.1834

>AT72567 WP_077355988.1 NZ_CP019508:2565473-2565700 [Brevundimonas sp. LM2]
MDELLSRITIEPDKNFGKPSIRRMRIRVQDVLEMLAAGDPPEEVLDAYPDLEPDDIRACIAYANAVITGRDIVVA

Download         Length: 228 bp

>AT72567 NZ_CP019508:2565473-2565700 [Brevundimonas sp. LM2]
ATGGATGAGCTTCTGTCCCGCATCACCATCGAGCCCGACAAGAACTTCGGGAAACCCAGCATCCGGCGCATGCGGATCCG
TGTGCAAGACGTGCTGGAGATGTTGGCGGCGGGCGATCCGCCAGAGGAAGTTCTCGATGCCTACCCGGATCTCGAGCCCG
ATGACATCCGAGCCTGCATTGCCTACGCCAATGCCGTGATCACCGGGCGGGATATCGTCGTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References