Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1577518..1578098 Replicon chromosome
Accession NZ_CP019508
Organism Brevundimonas sp. LM2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BZG35_RS07750 Protein ID WP_077355116.1
Coordinates 1577518..1577895 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BZG35_RS07755 Protein ID WP_077355117.1
Coordinates 1577892..1578098 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZG35_RS07725 1572949..1574571 - 1623 WP_077355112.1 response regulator -
BZG35_RS07730 1574768..1575481 + 714 WP_077357953.1 7-cyano-7-deazaguanine synthase QueC -
BZG35_RS07735 1575478..1576113 + 636 WP_077355113.1 7-carboxy-7-deazaguanine synthase -
BZG35_RS07740 1576115..1576387 - 273 WP_077355114.1 hypothetical protein -
BZG35_RS07745 1576431..1577516 - 1086 WP_077355115.1 chorismate synthase -
BZG35_RS07750 1577518..1577895 - 378 WP_077355116.1 PIN domain-containing protein Toxin
BZG35_RS07755 1577892..1578098 - 207 WP_077355117.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BZG35_RS07760 1578156..1578875 - 720 WP_077355118.1 molecular chaperone DnaJ -
BZG35_RS07765 1578952..1579626 + 675 WP_077355119.1 pyridoxamine 5'-phosphate oxidase -
BZG35_RS07770 1579630..1580262 - 633 WP_077355120.1 TetR/AcrR family transcriptional regulator -
BZG35_RS07775 1580315..1580968 - 654 WP_077355121.1 uridine kinase -
BZG35_RS07780 1580995..1581603 - 609 WP_077355122.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14344.54 Da        Isoelectric Point: 7.1863

>T72565 WP_077355116.1 NZ_CP019508:c1577895-1577518 [Brevundimonas sp. LM2]
MTFVLADTSVWVDHFRSRDPMLDQMLADSRVRMHPFVIGELAMGSLPRRPQVMQQLYDVRRIRSVSEEEVLHLVESGPHH
GTGLSWIDAHLLAAVLLVEDLCLWTRDRRLNQAAARYGRALAPHH

Download         Length: 378 bp

>T72565 NZ_CP019508:c1577895-1577518 [Brevundimonas sp. LM2]
TTGACGTTCGTCCTCGCGGACACTTCGGTCTGGGTCGATCATTTTCGGTCGCGCGACCCCATGCTCGACCAAATGCTGGC
CGATAGCCGGGTGCGTATGCATCCCTTCGTGATCGGCGAACTGGCGATGGGCAGCCTTCCACGGCGCCCCCAGGTCATGC
AGCAGCTCTATGATGTTCGACGGATCCGGAGCGTGTCCGAGGAAGAAGTCTTGCATCTGGTCGAAAGTGGCCCCCATCAC
GGGACGGGCCTCAGTTGGATTGATGCTCATCTCCTGGCAGCGGTTCTATTGGTCGAGGATTTGTGTCTCTGGACCCGCGA
CCGACGCCTGAATCAGGCCGCAGCCCGCTACGGGCGGGCCCTAGCGCCTCACCACTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7623.60 Da        Isoelectric Point: 5.0790

>AT72565 WP_077355117.1 NZ_CP019508:c1578098-1577892 [Brevundimonas sp. LM2]
MRTTITIDDALLARAAEYSGLEEPSAIIRHALREFVSTEASRRLAKLGGTMPDFEAGPRKRYWGVEED

Download         Length: 207 bp

>AT72565 NZ_CP019508:c1578098-1577892 [Brevundimonas sp. LM2]
ATGAGGACCACGATCACGATTGACGATGCCCTGCTGGCTCGAGCCGCGGAATATAGCGGTCTGGAGGAGCCGTCGGCGAT
CATCCGGCATGCGCTGCGCGAGTTTGTCTCGACCGAGGCATCGCGGCGTCTCGCCAAGCTAGGTGGAACCATGCCCGATT
TCGAGGCCGGCCCTCGCAAGCGCTATTGGGGCGTTGAGGAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References