Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 468901..469586 Replicon plasmid pSymA
Accession NZ_CP019486
Organism Sinorhizobium meliloti strain B399

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BWO90_RS02675 Protein ID WP_095918854.1
Coordinates 468901..469320 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BWO90_RS02680 Protein ID WP_088196198.1
Coordinates 469317..469586 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWO90_RS02655 464936..465550 + 615 WP_013845397.1 response regulator transcription factor -
BWO90_RS02660 465619..466053 + 435 WP_127570021.1 response regulator -
BWO90_RS02665 466286..467923 + 1638 WP_014531600.1 arylsulfatase -
BWO90_RS02670 468001..468432 + 432 WP_014990025.1 hypothetical protein -
BWO90_RS02675 468901..469320 - 420 WP_095918854.1 type II toxin-antitoxin system VapC family toxin Toxin
BWO90_RS02680 469317..469586 - 270 WP_088196198.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BWO90_RS02685 469942..470815 - 874 Protein_467 LysR family transcriptional regulator -
BWO90_RS02700 471820..472133 + 314 Protein_468 hypothetical protein -
BWO90_RS02705 472241..472621 - 381 WP_095918856.1 transcriptional regulator -
BWO90_RS02710 472774..473970 - 1197 WP_010969783.1 IS256-like element ISRm5 family transposase -
BWO90_RS02715 474069..474272 + 204 Protein_471 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1117190 1117190


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14876.18 Da        Isoelectric Point: 5.1858

>T72548 WP_095918854.1 NZ_CP019486:c469320-468901 [Sinorhizobium meliloti]
VSRLYMLDTNIVSELARNPQGAVTKRIAEIGPDAICVSIITAAELRYRCAKKGSSKLLAQIETILGSMQVLALDVPADAE
YGGIRAELEAAGKPIGPNDLFIAAHACMLGAVLVTANSSEFTRVRDLKVENWLDFTSQG

Download         Length: 420 bp

>T72548 NZ_CP019486:c469320-468901 [Sinorhizobium meliloti]
GTGAGCAGGCTCTACATGCTGGACACCAATATCGTTTCCGAGCTTGCGCGAAACCCACAGGGGGCTGTCACTAAACGCAT
TGCCGAGATAGGACCGGATGCAATCTGCGTCAGCATCATTACGGCGGCAGAGTTACGCTATAGATGCGCCAAGAAGGGAT
CATCGAAACTGCTGGCGCAGATCGAGACCATTCTTGGAAGTATGCAAGTGCTTGCGCTCGATGTGCCTGCTGATGCCGAA
TACGGCGGCATCCGGGCTGAACTGGAGGCTGCTGGTAAGCCCATCGGCCCGAATGACCTGTTCATCGCCGCTCATGCCTG
TATGCTTGGAGCGGTGCTGGTAACGGCCAACAGTAGCGAGTTCACACGCGTTCGTGATCTCAAGGTCGAGAACTGGCTGG
ATTTCACTTCTCAGGGTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10202.68 Da        Isoelectric Point: 4.5716

>AT72548 WP_088196198.1 NZ_CP019486:c469586-469317 [Sinorhizobium meliloti]
MPQLRHNEPTPPREAKLFRNNRSQAVRIPADFELPGDRVMIHRDGDRLIIEPVLRKNLLEVLAGLEPLGSEDEFPDVDET
LLPVKEIDL

Download         Length: 270 bp

>AT72548 NZ_CP019486:c469586-469317 [Sinorhizobium meliloti]
ATGCCCCAACTCCGACACAACGAACCAACACCGCCAAGGGAAGCCAAGCTCTTCCGAAATAATAGAAGTCAGGCTGTACG
TATCCCCGCTGATTTTGAGCTTCCCGGCGATCGGGTGATGATCCATCGGGACGGAGATCGGCTGATAATAGAGCCGGTGC
TCCGCAAGAACTTGCTGGAAGTGCTGGCTGGTTTGGAGCCGCTCGGGTCTGAAGATGAGTTCCCTGACGTTGACGAAACC
CTGCTGCCGGTGAAGGAAATCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References