72542

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2158529..2159183 Replicon chromosome
Accession NZ_CP019485
Organism Sinorhizobium meliloti strain B401

Toxin (Protein)


Gene name hicA Uniprot ID H0G1A3
Locus tag BWO76_RS24475 Protein ID WP_003530010.1
Coordinates 2158529..2158717 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q92NX0
Locus tag BWO76_RS24480 Protein ID WP_010969659.1
Coordinates 2158722..2159183 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWO76_RS24460 2155095..2156405 + 1311 WP_010969656.1 HlyD family type I secretion periplasmic adaptor subunit -
BWO76_RS24465 2156430..2157401 - 972 WP_017265202.1 glycosyltransferase family 2 protein -
BWO76_RS24470 2157582..2158352 - 771 WP_010969658.1 hypothetical protein -
BWO76_RS24475 2158529..2158717 + 189 WP_003530010.1 type II toxin-antitoxin system HicA family toxin Toxin
BWO76_RS24480 2158722..2159183 + 462 WP_010969659.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BWO76_RS24490 2159502..2160419 - 918 WP_003530005.1 PhzF family phenazine biosynthesis protein -
BWO76_RS24495 2160596..2161345 - 750 WP_010969660.1 NUDIX hydrolase -
BWO76_RS24500 2161348..2162454 - 1107 WP_003530001.1 endonuclease -
BWO76_RS24505 2162605..2163048 - 444 WP_003529999.1 TIGR02594 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6971.15 Da        Isoelectric Point: 11.0889

>T72542 WP_003530010.1 NZ_CP019485:2158529-2158717 [Sinorhizobium meliloti]
MKSGDIIAALQKDGWYEVATKGSHVQFKHPKKHGRVTVPHPKRDLPIGTLRSIEKQSGLKLR

Download         Length: 189 bp

>T72542 NZ_CP019485:2158529-2158717 [Sinorhizobium meliloti]
ATGAAGAGCGGCGACATTATTGCAGCATTGCAGAAGGACGGATGGTACGAGGTTGCGACCAAGGGCAGCCACGTTCAATT
CAAACATCCGAAAAAGCACGGCCGGGTTACCGTTCCTCACCCGAAGAGGGATCTACCAATCGGTACCCTCAGGAGCATTG
AAAAGCAGTCCGGTTTGAAATTGAGGTAA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16293.17 Da        Isoelectric Point: 4.3990

>AT72542 WP_010969659.1 NZ_CP019485:2158722-2159183 [Sinorhizobium meliloti]
MRNYIGLIHKDAESDYGVSFPDFSGVVTAGADLDDARAMAEEALALHIEGLVEDGEAIPEPSSLEVVMSDAENRDCVAIL
VAVKTEAKRAIRVNVTLPEGVLKQIDAFAEAHGLTRSGFLARAATHEIERANDGHDAYAESRLSALGTSSKNV

Download         Length: 462 bp

>AT72542 NZ_CP019485:2158722-2159183 [Sinorhizobium meliloti]
ATGCGCAACTATATCGGATTGATCCACAAGGACGCCGAGAGCGATTACGGCGTTTCCTTTCCTGATTTTTCCGGCGTCGT
GACCGCCGGTGCCGACCTCGACGACGCGCGCGCTATGGCAGAGGAAGCCTTGGCCTTGCATATTGAAGGGCTGGTAGAGG
ACGGCGAGGCCATCCCGGAGCCCTCCTCCCTTGAGGTTGTCATGTCCGACGCCGAGAACAGGGATTGCGTCGCTATTCTC
GTCGCGGTGAAAACCGAGGCAAAAAGAGCCATTCGAGTGAACGTTACGCTTCCCGAAGGTGTCCTGAAGCAGATAGATGC
CTTCGCCGAAGCCCACGGCCTTACGCGGTCTGGATTTCTTGCTCGTGCTGCAACGCACGAGATCGAACGGGCAAATGACG
GCCACGACGCCTATGCGGAATCCCGCTTGTCGGCTTTGGGCACTTCCAGCAAAAATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G1A3

Antitoxin

Source ID Structure
AlphaFold DB Q92NX0

References