Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_31(antitoxin)
Location 2647385..2648598 Replicon chromosome
Accession NZ_CP019449
Organism Sphingopyxis sp. QXT-31

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BWQ93_RS12735 Protein ID WP_077030874.1
Coordinates 2648008..2648598 (+) Length 197 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BWQ93_RS12730 Protein ID WP_077032388.1
Coordinates 2647385..2647960 (+) Length 192 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWQ93_RS12705 2642764..2643534 - 771 WP_083720859.1 DUF448 domain-containing protein -
BWQ93_RS12710 2643515..2645161 - 1647 WP_077030871.1 transcription termination/antitermination protein NusA -
BWQ93_RS12715 2645161..2645715 - 555 WP_198040378.1 ribosome maturation protein RimP -
BWQ93_RS12720 2645901..2646791 + 891 WP_077030872.1 FkbM family methyltransferase -
BWQ93_RS12725 2646796..2647302 - 507 WP_077030873.1 hypothetical protein -
BWQ93_RS12730 2647385..2647960 + 576 WP_077032388.1 helix-turn-helix domain-containing protein Antitoxin
BWQ93_RS12735 2648008..2648598 + 591 WP_077030874.1 HD domain-containing protein Toxin
BWQ93_RS12740 2648769..2649911 + 1143 WP_077030875.1 cell wall hydrolase -
BWQ93_RS12745 2650025..2651740 - 1716 WP_198040379.1 DUF853 family protein -
BWQ93_RS12750 2651811..2652587 - 777 WP_077030876.1 TIGR02186 family protein -
BWQ93_RS12755 2652584..2653492 - 909 WP_077030877.1 sulfite exporter TauE/SafE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(22-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-48)


Sequences

Toxin        


Download         Length: 197 a.a.        Molecular weight: 21624.67 Da        Isoelectric Point: 5.3267

>T72475 WP_077030874.1 NZ_CP019449:2648008-2648598 [Sphingopyxis sp. QXT-31]
MTNDQPIDPSRLAAILAFVQAAEKLKDTLRSGITASGRAESTAEHSWRLCLMAMLFDRELAGYDRLKLLRLCIVHDLGEA
ISGDVPATCQRPGDDRAARERADLQSLCAPLPGDLAREILDLWDEYGAAATPEAQMVKGLDKLETMLQHLIGRNAPGFDY
RFNLSYGAQHTGRHPLLAQMRGLVDAATRERIAELE

Download         Length: 591 bp

>T72475 NZ_CP019449:2648008-2648598 [Sphingopyxis sp. QXT-31]
ATGACGAACGATCAGCCCATCGACCCGTCGCGGCTCGCCGCGATTCTCGCCTTCGTGCAGGCCGCGGAGAAGCTCAAAGA
CACGCTGCGCAGCGGCATCACGGCGAGCGGCCGCGCCGAAAGCACCGCCGAGCATAGCTGGCGGCTTTGCCTGATGGCGA
TGCTCTTCGACCGCGAACTCGCCGGATACGACCGGCTGAAATTGCTCAGGCTGTGCATCGTCCACGATCTGGGCGAAGCG
ATTTCGGGCGACGTCCCCGCGACGTGCCAGCGGCCGGGCGACGACCGCGCCGCGCGCGAACGCGCCGACCTTCAATCCCT
GTGCGCCCCGCTGCCCGGCGATCTCGCACGCGAAATCCTGGATTTGTGGGACGAATATGGCGCCGCCGCGACGCCCGAGG
CGCAGATGGTCAAGGGCTTGGACAAGCTTGAGACGATGCTCCAGCACCTGATCGGCCGCAACGCGCCCGGCTTCGATTAC
CGGTTCAATCTGAGCTACGGCGCTCAGCATACGGGCAGGCATCCGCTGCTCGCGCAGATGCGCGGGCTGGTCGATGCCGC
GACGCGCGAGCGCATCGCCGAGCTGGAGTGA

Antitoxin


Download         Length: 192 a.a.        Molecular weight: 20737.68 Da        Isoelectric Point: 9.2808

>AT72475 WP_077032388.1 NZ_CP019449:2647385-2647960 [Sphingopyxis sp. QXT-31]
MTHAVLPCRDHLGASLRRWRALNRVKQAALAEELGVSQTTVSRWEAGTLPLGPREEDRVTQLLAARPGSAADRALLDLVR
QSPRPVHLICDLTHRLFAASPARIAGWRVGIDDLVGRSLWRFASPGIAAGEAALDTLGWYAPVAPAVTIDTEEADFGELS
IAAGRLRYTRMPLSDGSFARLVEDGARRARA

Download         Length: 576 bp

>AT72475 NZ_CP019449:2647385-2647960 [Sphingopyxis sp. QXT-31]
ATGACCCACGCCGTCCTGCCCTGCCGCGACCATCTAGGCGCCTCGCTGCGGCGCTGGCGCGCGCTCAATCGCGTCAAGCA
GGCCGCGCTCGCCGAGGAACTCGGCGTGTCGCAGACGACGGTATCGCGCTGGGAGGCGGGGACACTGCCGCTCGGCCCGC
GCGAGGAGGACCGGGTGACGCAGCTGCTCGCGGCGCGGCCGGGCTCGGCCGCCGATCGCGCGCTGCTCGACCTCGTCCGC
CAGTCGCCGCGCCCGGTGCACCTGATCTGCGACCTGACGCACCGGCTGTTCGCGGCGTCGCCGGCGCGGATCGCCGGGTG
GCGGGTCGGGATCGACGACCTCGTCGGCCGCTCGCTATGGCGCTTTGCCTCGCCGGGCATCGCCGCGGGCGAAGCGGCGC
TCGATACGCTCGGCTGGTACGCGCCGGTCGCGCCCGCGGTCACGATCGACACCGAGGAGGCCGATTTCGGCGAACTCAGC
ATCGCCGCGGGCCGCCTGCGATACACGCGCATGCCGCTGTCGGACGGCAGCTTCGCGCGCCTCGTCGAGGATGGCGCGCG
CCGGGCCCGCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References