Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 1462741..1463260 Replicon chromosome
Accession NZ_CP019445
Organism Kosakonia cowanii JCM 10956 = DSM 18146 strain 888-76

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag BWI95_RS06735 Protein ID WP_054803376.1
Coordinates 1462979..1463260 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID -
Locus tag BWI95_RS06730 Protein ID WP_042717989.1
Coordinates 1462741..1462989 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWI95_RS06715 1458506..1459765 - 1260 WP_023480794.1 oligosaccharide MFS transporter -
BWI95_RS06720 1459823..1461649 - 1827 WP_076769221.1 DUF2264 domain-containing protein -
BWI95_RS06725 1461815..1462690 + 876 WP_054803377.1 AraC family transcriptional regulator -
BWI95_RS06730 1462741..1462989 + 249 WP_042717989.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BWI95_RS06735 1462979..1463260 + 282 WP_054803376.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BWI95_RS06740 1463614..1465506 - 1893 WP_042717986.1 DNA topoisomerase IV subunit B -
BWI95_RS06745 1465546..1466121 - 576 WP_054803018.1 esterase YqiA -
BWI95_RS06750 1466121..1466948 - 828 WP_076769222.1 3',5'-cyclic-AMP phosphodiesterase -
BWI95_RS06755 1466973..1467395 - 423 WP_023480711.1 DUF1249 family protein -
BWI95_RS06760 1467392..1468024 - 633 WP_023480789.1 ADP-ribose diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10928.74 Da        Isoelectric Point: 10.6500

>T72459 WP_054803376.1 NZ_CP019445:1462979-1463260 [Kosakonia cowanii JCM 10956 = DSM 18146]
MTYKLAFNVSALKEWKKLGSTVREQFKKKLQERLENPRVPAAQLHGRKDQYKIKLRGAGYRLVYKVEEEIITVTVIGVGK
RENDEIYTATRFR

Download         Length: 282 bp

>T72459 NZ_CP019445:1462979-1463260 [Kosakonia cowanii JCM 10956 = DSM 18146]
ATGACCTATAAGCTGGCGTTCAACGTATCGGCATTAAAGGAGTGGAAGAAGCTGGGAAGCACCGTTCGCGAACAGTTCAA
AAAGAAGCTTCAGGAGCGGCTCGAAAACCCGCGCGTCCCGGCAGCACAGCTTCATGGGCGCAAAGATCAGTACAAAATTA
AGCTACGCGGTGCGGGATACCGGCTGGTCTATAAAGTCGAAGAGGAGATCATCACCGTGACGGTGATCGGTGTGGGCAAA
CGCGAGAACGATGAGATCTACACAGCCACACGCTTCAGATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9097.37 Da        Isoelectric Point: 3.9490

>AT72459 WP_042717989.1 NZ_CP019445:1462741-1462989 [Kosakonia cowanii JCM 10956 = DSM 18146]
MPFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYARLMEMLEDEELGRIADERADEPTIEVKLD
DL

Download         Length: 249 bp

>AT72459 NZ_CP019445:1462741-1462989 [Kosakonia cowanii JCM 10956 = DSM 18146]
ATGCCATTCCAGATTCTGACGACCACCGCAGCCAGCATCACCGAACTGAAACGTGACCCGATGGGAACATTTAATGCCGG
TGAAGGCGCGCCGGTTGCCATTCTTAATCGCAATGAACCCGCGTTCTACTGCGTCCCGCCCGCGCTCTATGCACGCCTGA
TGGAGATGCTCGAAGACGAAGAGCTGGGGCGCATTGCGGACGAACGTGCTGATGAACCCACCATCGAGGTCAAGCTTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References