Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 161025..162648 Replicon plasmid unnamed1
Accession NZ_CP019443
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 81741

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag BVA04_RS26365 Protein ID WP_000088046.1
Coordinates 161025..162350 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag BVA04_RS26370 Protein ID WP_024136327.1
Coordinates 162355..162648 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVA04_RS26330 157290..157670 + 381 WP_001426317.1 hypothetical protein -
BVA04_RS26335 157728..158393 + 666 WP_000490638.1 hypothetical protein -
BVA04_RS26340 158437..159134 - 698 Protein_168 IS1 family transposase -
BVA04_RS26350 159418..160233 - 816 WP_053276223.1 HNH endonuclease -
BVA04_RS26355 160246..160656 - 411 WP_000985911.1 hypothetical protein -
BVA04_RS26360 160758..160964 - 207 WP_000134171.1 hypothetical protein -
BVA04_RS26365 161025..162350 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
BVA04_RS26370 162355..162648 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
BVA04_RS26380 163252..163644 - 393 WP_000341066.1 hypothetical protein -
BVA04_RS26385 164017..164358 + 342 WP_001151575.1 hypothetical protein -
BVA04_RS26390 164450..164641 + 192 WP_000398480.1 hypothetical protein -
BVA04_RS26395 164691..164972 + 282 WP_000077926.1 hypothetical protein -
BVA04_RS26400 165535..166776 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..233802 233802


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 65070.07 Da        Isoelectric Point: 5.5500

>T72454 WP_000088046.1 NZ_CP019443:c162350-161025 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 1326 bp

>T72454 NZ_CP019443:c162350-161025 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Antitoxin


Download         Length: 98 a.a.        Molecular weight: 14441.32 Da        Isoelectric Point: 5.5500

>AT72454 WP_024136327.1 NZ_CP019443:c162648-162355 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFF

Download         Length: 294 bp

>AT72454 NZ_CP019443:c162648-162355 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References