Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 5072436..5073054 Replicon chromosome
Accession NZ_CP019432
Organism Pseudomonas sp. S49

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag PspS49_RS22330 Protein ID WP_197678427.1
Coordinates 5072436..5072747 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag PspS49_RS22335 Protein ID WP_150775215.1
Coordinates 5072734..5073054 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspS49_RS22305 5068156..5069346 - 1191 WP_160041497.1 hypothetical protein -
PspS49_RS22310 5069433..5070152 - 720 WP_137218980.1 hypothetical protein -
PspS49_RS22315 5070230..5071045 - 816 WP_150750313.1 sulfite exporter TauE/SafE family protein -
PspS49_RS22320 5071158..5071925 + 768 WP_160041499.1 helix-turn-helix transcriptional regulator -
PspS49_RS22325 5072019..5072336 + 318 WP_160041501.1 XRE family transcriptional regulator -
PspS49_RS22330 5072436..5072747 + 312 WP_197678427.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PspS49_RS22335 5072734..5073054 + 321 WP_150775215.1 helix-turn-helix domain-containing protein Antitoxin
PspS49_RS22340 5073066..5074121 - 1056 WP_160041503.1 MBL fold metallo-hydrolase -
PspS49_RS22345 5074337..5074945 + 609 WP_160041505.1 TetR/AcrR family transcriptional regulator -
PspS49_RS22350 5075102..5076169 + 1068 WP_160042572.1 diguanylate cyclase -
PspS49_RS22355 5076361..5077680 + 1320 WP_160041507.1 PAS domain-containing methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5066092..5080340 14248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11373.79 Da        Isoelectric Point: 7.2750

>T72450 WP_197678427.1 NZ_CP019432:5072436-5072747 [Pseudomonas sp. S49]
MPTDVQDVFGYALDLAQSGLKHPDAKPLKGFGGAGVLELIEDFDTNTYRAIYTVRFGSAIYVLHCFQKKSTTGIKTAQSD
IDLIRNRLRAAQDHAKGSENDRN

Download         Length: 312 bp

>T72450 NZ_CP019432:5072436-5072747 [Pseudomonas sp. S49]
ATGCCCACAGACGTACAGGATGTTTTTGGTTATGCACTGGATTTGGCCCAGAGTGGCTTGAAGCATCCGGATGCAAAACC
CCTGAAAGGGTTTGGAGGCGCAGGTGTGCTAGAGCTGATCGAAGACTTCGATACCAACACCTACCGCGCCATTTACACGG
TTCGTTTCGGCAGTGCCATTTATGTATTGCACTGCTTTCAAAAGAAGTCGACTACCGGAATCAAAACGGCTCAGTCCGAC
ATTGATCTGATACGAAACCGTCTTCGAGCCGCTCAGGATCACGCGAAAGGATCAGAAAATGATAGAAATTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11777.76 Da        Isoelectric Point: 9.0613

>AT72450 WP_150775215.1 NZ_CP019432:5072734-5073054 [Pseudomonas sp. S49]
MIEIEKGSGNVYEDLELPNASEMQVKSQLAAKIGEIIKARHLTQIQASEILGLSQPKLSEMLRGKFRGISEAKMMECLSH
LGRDVQIVVKSAPRSRKEGRIEVVFA

Download         Length: 321 bp

>AT72450 NZ_CP019432:5072734-5073054 [Pseudomonas sp. S49]
ATGATAGAAATTGAAAAAGGTAGCGGGAACGTCTACGAAGACCTCGAACTGCCCAATGCTAGTGAAATGCAGGTTAAGTC
GCAGCTCGCGGCGAAGATCGGCGAGATCATCAAGGCTCGCCATCTCACTCAGATTCAGGCGTCTGAAATCCTTGGATTAT
CCCAGCCGAAACTTTCCGAAATGCTGCGGGGAAAATTTCGAGGAATCAGTGAAGCCAAAATGATGGAATGTCTTTCACAT
CTTGGGCGAGACGTGCAGATCGTAGTGAAATCGGCCCCCCGATCACGGAAAGAAGGCCGAATTGAAGTGGTGTTTGCTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References