Detailed information of TA system TA072449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3026635..3027154
• Replicon: chromosome
• Accession: NZ_CP019432
• Organism: Pseudomonas sp. S49

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PspS49_RS13350
• Protein ID: WP_127927109.1
• Coordinates: 3026873..3027154 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4R7V066
• Locus tag: PspS49_RS13345
• Protein ID: WP_038368375.1
• Coordinates: 3026635..3026883 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PspS49_RS13335	3021685..3024321	+	2637	WP_160039705.1	hypothetical protein	-
PspS49_RS13340	3024780..3026339	+	1560	WP_160039707.1	TerC family protein	-
PspS49_RS13345	3026635..3026883	+	249	WP_038368375.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PspS49_RS13350	3026873..3027154	+	282	WP_127927109.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PspS49_RS13355	3027196..3027663	-	468	WP_127927111.1	hypothetical protein	-
PspS49_RS13360	3027720..3028151	-	432	WP_127927113.1	thioredoxin family protein	-
PspS49_RS13365	3028243..3028647	-	405	WP_150774548.1	hypothetical protein	-
PspS49_RS13370	3029072..3029920	+	849	WP_160039709.1	transporter substrate-binding domain-containing protein	-
PspS49_RS13375	3029973..3030635	+	663	WP_038368362.1	amino acid ABC transporter permease	-
PspS49_RS13380	3030645..3031307	+	663	WP_127927117.1	amino acid ABC transporter permease	-
PspS49_RS13385	3031304..3032095	+	792	WP_150752044.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10723.58 Da
• Isoelectric Point: 10.5377

>T72449 WP_127927109.1 NZ_CP019432:3026873-3027154 [Pseudomonas sp. S49]
MTYELEFSEKAWKEWEKLGAGLRDQFKKKLAERLLNPHVPADRLKGLGNAYKIKLRSAGYRMVYRVKDEVLVVAVIAVGK
RARGEIYTEAAKR

Nucleotide

• Length: 282 bp

>T72449 NZ_CP019432:3026873-3027154 [Pseudomonas sp. S49]
ATGACCTATGAGCTGGAATTTTCTGAAAAGGCCTGGAAAGAGTGGGAGAAGCTGGGCGCAGGTCTACGAGATCAGTTCAA
GAAAAAACTAGCGGAGCGGCTGCTTAATCCACATGTACCGGCGGATCGACTCAAAGGCCTCGGTAATGCATACAAAATTA
AGCTGCGGAGCGCCGGATATCGGATGGTGTATCGGGTCAAGGATGAAGTATTGGTGGTCGCGGTGATAGCCGTTGGCAAG
CGAGCGCGAGGCGAAATCTATACAGAGGCTGCCAAGCGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8971.41 Da
• Isoelectric Point: 5.0492

>AT72449 WP_038368375.1 NZ_CP019432:3026635-3026883 [Pseudomonas sp. S49]
MAHIVLSHVVASISELKKNPMGTVAAGGGRSVAILNRNEPAFYCVPAKEYEAMMTRLDDLELIALCKERENDPTIKVSID
DL

Nucleotide

• Length: 249 bp

>AT72449 NZ_CP019432:3026635-3026883 [Pseudomonas sp. S49]
ATGGCACACATCGTTCTTTCTCACGTAGTAGCGAGTATTTCCGAATTGAAAAAAAATCCGATGGGCACTGTAGCTGCTGG
AGGTGGACGCTCTGTAGCGATTCTCAACCGAAATGAACCAGCGTTTTATTGCGTACCTGCCAAAGAATACGAGGCAATGA
TGACGCGCCTTGATGATCTGGAGTTGATCGCGCTTTGCAAGGAGCGAGAAAACGACCCCACCATCAAGGTCTCAATAGAT
GACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A4R7V066