72446

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1905120..1905739 Replicon chromosome
Accession NZ_CP019432
Organism Pseudomonas sp. S49

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PspS49_RS08390 Protein ID WP_127926334.1
Coordinates 1905120..1905335 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PspS49_RS08395 Protein ID WP_123374656.1
Coordinates 1905335..1905739 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspS49_RS08365 1900298..1902286 + 1989 WP_160038805.1 heme lyase CcmF/NrfE family subunit -
PspS49_RS08370 1902283..1902819 + 537 WP_007919961.1 DsbE family thiol:disulfide interchange protein -
PspS49_RS08375 1902816..1903286 + 471 WP_160038807.1 cytochrome c-type biogenesis protein CcmH -
PspS49_RS08380 1903283..1904485 + 1203 WP_150752212.1 c-type cytochrome biogenesis protein CcmI -
PspS49_RS08385 1904511..1904915 + 405 WP_016987493.1 hypothetical protein -
PspS49_RS08390 1905120..1905335 + 216 WP_127926334.1 type II toxin-antitoxin system HicA family toxin Toxin
PspS49_RS08395 1905335..1905739 + 405 WP_123374656.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PspS49_RS08400 1905809..1906996 - 1188 WP_160038809.1 MFS transporter -
PspS49_RS08405 1907241..1907861 + 621 WP_160038811.1 hypothetical protein -
PspS49_RS08410 1908101..1909099 - 999 WP_038363913.1 sulfate ABC transporter substrate-binding protein -
PspS49_RS08415 1909204..1910028 - 825 WP_038363916.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8105.28 Da        Isoelectric Point: 10.0381

>T72446 WP_127926334.1 NZ_CP019432:1905120-1905335 [Pseudomonas sp. S49]
MVQSRQLIKELEEAGWALDRITGSHHIFTHRYNPYTIPVPHPKKDLPLGTVKSIRRRAGLYNPPASFEGDP

Download         Length: 216 bp

>T72446 NZ_CP019432:1905120-1905335 [Pseudomonas sp. S49]
TTGGTACAAAGCAGGCAATTGATCAAGGAGCTGGAGGAGGCTGGCTGGGCGCTGGATCGGATCACCGGCAGTCATCACAT
CTTCACTCACCGATACAACCCGTACACGATTCCCGTCCCTCACCCGAAAAAGGATTTGCCGCTGGGGACGGTCAAAAGCA
TCAGGAGGCGTGCCGGGTTGTACAACCCGCCAGCCAGTTTCGAAGGAGATCCATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14803.78 Da        Isoelectric Point: 4.3945

>AT72446 WP_123374656.1 NZ_CP019432:1905335-1905739 [Pseudomonas sp. S49]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEDAYKAAVEVAHIMLQEIAADGESIPMPTSASAHRSNPEFADMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp

>AT72446 NZ_CP019432:1905335-1905739 [Pseudomonas sp. S49]
ATGCAATATCCAATCTGCATCGAGTGGGGTGACGAAAATACCGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCCGT
TACAGCAGGGGATAGCTTTGAAGATGCCTACAAGGCGGCGGTTGAAGTCGCCCACATCATGCTGCAGGAGATTGCGGCGG
ACGGGGAGTCGATTCCTATGCCGACTTCGGCATCCGCTCATCGCAGTAATCCCGAATTTGCCGATATGGGCTGGGGCATG
CTTGAGCTGGACATTTCGCCCTATCTCGGCAAGACCGAGAAGGTCAACGTAACGCTGCCCGGTTACGTGATTCAGCGCAT
CGATCGTTATGTGCGCGAGCACAACGTCAAAAGCCGCTCCTCCTTTCTGGCGGATGCGGCGATGGAAAAGCTGGTTCGAT
ATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References