Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1605701..1606298 Replicon chromosome
Accession NZ_CP019432
Organism Pseudomonas sp. S49

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PspS49_RS07080 Protein ID WP_150773830.1
Coordinates 1606143..1606298 (-) Length 52 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PspS49_RS07075 Protein ID WP_137218087.1
Coordinates 1605701..1606108 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspS49_RS07050 1601307..1602077 + 771 WP_150749329.1 trans-aconitate 2-methyltransferase -
PspS49_RS07055 1602256..1602984 - 729 WP_150749328.1 class I SAM-dependent methyltransferase -
PspS49_RS07060 1603549..1603911 + 363 WP_150749327.1 hypothetical protein -
PspS49_RS07065 1603988..1605247 - 1260 WP_127926174.1 type II toxin-antitoxin system HipA family toxin -
PspS49_RS07070 1605240..1605557 - 318 WP_127930362.1 helix-turn-helix transcriptional regulator -
PspS49_RS07075 1605701..1606108 - 408 WP_137218087.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PspS49_RS07080 1606143..1606298 - 156 WP_150773830.1 type II toxin-antitoxin system HicA family toxin Toxin
PspS49_RS07090 1606809..1607693 - 885 WP_064119706.1 alpha/beta hydrolase -
PspS49_RS07095 1608010..1608702 - 693 WP_160038649.1 pseudouridine synthase -
PspS49_RS07100 1608736..1608966 - 231 WP_127926178.1 cysteine-rich CWC family protein -
PspS49_RS07105 1608959..1610446 - 1488 WP_127926179.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-49)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5826.89 Da        Isoelectric Point: 11.2584

>T72445 WP_150773830.1 NZ_CP019432:c1606298-1606143 [Pseudomonas sp. S49]
VNSRFLIGQLVAYGWYLVRVRGSHHHFKHPTKPGLVTVPHPTKDLLKQALL

Download         Length: 156 bp

>T72445 NZ_CP019432:c1606298-1606143 [Pseudomonas sp. S49]
GTGAATAGCCGTTTTTTAATCGGTCAACTTGTTGCATACGGTTGGTATTTAGTGAGAGTCAGAGGCAGTCACCATCATTT
CAAGCATCCGACCAAGCCTGGACTGGTCACGGTGCCGCATCCGACGAAAGATCTGTTGAAGCAAGCGCTGCTTTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14416.43 Da        Isoelectric Point: 4.4904

>AT72445 WP_137218087.1 NZ_CP019432:c1606108-1605701 [Pseudomonas sp. S49]
MLYPIAISIGDEEHAWGVEVPDIPGCFSAGDDLDDAVAMAREAIEGHFEILAEDGAPIPAASKLGVNVANPKYAGCAWAV
VDIDVVKYLGKAQKLNITLPGHLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Download         Length: 408 bp

>AT72445 NZ_CP019432:c1606108-1605701 [Pseudomonas sp. S49]
ATGCTCTACCCGATTGCGATTTCAATAGGTGATGAGGAACACGCCTGGGGCGTGGAGGTGCCGGACATTCCGGGCTGTTT
TTCGGCTGGCGATGATCTGGATGATGCCGTCGCCATGGCTCGCGAAGCCATCGAGGGGCATTTCGAAATTTTGGCTGAGG
ACGGTGCGCCGATCCCGGCTGCGAGCAAACTCGGCGTGAACGTCGCCAATCCGAAGTACGCAGGATGTGCATGGGCCGTG
GTCGATATAGATGTCGTGAAGTACTTGGGCAAAGCCCAGAAACTCAACATCACTTTGCCGGGGCACTTGCTCAACCGCAT
TGATGAATATGTGTTGCATCACCCGGAAGAAAAAAGCCGCTCGGGCTTTCTGGCGTCGGCGGCTCTGAAAGTTTTGCAGC
AGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References