Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1770000..1771477 Replicon chromosome
Accession NZ_CP019430
Organism Oxalobacter formigenes OXCC13

Toxin (Protein)


Gene name HipA1 Uniprot ID C3X8C7
Locus tag BRW84_RS08365 Protein ID WP_005879940.1
Coordinates 1770000..1771256 (-) Length 419 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag BRW84_RS08370 Protein ID WP_005879938.1
Coordinates 1771253..1771477 (-) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BRW84_RS08350 1766765..1767250 - 486 WP_036602666.1 hypothetical protein -
BRW84_RS08355 1768193..1769059 + 867 WP_005879944.1 hypothetical protein -
BRW84_RS08360 1769116..1769991 + 876 WP_005879942.1 hypothetical protein -
BRW84_RS08365 1770000..1771256 - 1257 WP_005879940.1 type II toxin-antitoxin system HipA family toxin Toxin
BRW84_RS08370 1771253..1771477 - 225 WP_005879938.1 helix-turn-helix transcriptional regulator Antitoxin
BRW84_RS08375 1771666..1772043 - 378 WP_036602664.1 DUF1622 domain-containing protein -
BRW84_RS08380 1772306..1772953 + 648 WP_036603576.1 NAD(P)H-binding protein -
BRW84_RS08385 1772965..1773420 + 456 WP_036602661.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(146-351)

Antitoxin

(15-66)


Sequences


Toxin        


Download         Length: 419 a.a.        Molecular weight: 46365.63 Da        Isoelectric Point: 6.7525

>T72439 WP_005879940.1 NZ_CP019430:c1771256-1770000 [Oxalobacter formigenes OXCC13]
MSRILDVYLHEKMAGTLAQNENGQLVFKYNSNYLDSNGMAISVSMPLRDEPYPDRIARPYFAGLLPDERARRRLAAVLGV
SDENVFGLLEIIGGECAGALSLLPQGQPLPDFSTGTVEVLDGKRLAELLDLLRQKPLLGGVEGIRLSLAGAQDKLAVCFI
DGQIFLPKNGLPTTHILKPFIEGLSGTVENEVFCMMLAGRVGLDAPVVSKGMAGNTGFILVERYDRVREENGRILRLHQE
DFCQALGVPPEIKYESEGGPGIASSQALIQNVTQRPAADRRAFQQRVIFHYLVGNADAHAKNYSLLYQGKTPVLAPVYDV
VCTDVYSLAKNMAMKIGERSLPDTIRLEDWQKMVPDTRVAKRILSDDLLRMANGIEIEADRLLEELNDQNLYHPVLKKIR
RTIGVRVRTIQKLMEKIA

Download         Length: 1257 bp

>T72439 NZ_CP019430:c1771256-1770000 [Oxalobacter formigenes OXCC13]
ATGAGTCGCATTCTTGATGTTTACCTTCATGAAAAGATGGCGGGTACGCTGGCGCAAAATGAGAATGGCCAACTTGTTTT
CAAATATAACAGTAATTATCTGGATTCAAACGGGATGGCAATTTCAGTATCGATGCCTTTACGTGATGAGCCTTACCCGG
ACAGGATCGCTCGTCCGTACTTTGCCGGTTTGTTGCCGGACGAACGTGCGCGACGTCGTCTTGCGGCTGTGTTGGGTGTT
TCTGATGAAAATGTTTTCGGTTTGCTGGAGATAATCGGTGGTGAATGTGCAGGTGCACTTTCCCTGTTACCGCAAGGACA
ACCGTTGCCCGATTTTTCTACCGGAACTGTCGAGGTACTCGACGGGAAACGTCTTGCTGAACTGCTGGACCTGTTACGGC
AAAAACCATTGCTTGGAGGTGTGGAAGGAATTCGCTTATCTCTTGCCGGGGCACAGGATAAACTGGCCGTTTGTTTCATT
GACGGGCAAATTTTTTTGCCCAAAAACGGACTTCCGACCACACATATTCTCAAACCTTTTATCGAAGGATTGAGCGGAAC
GGTTGAAAACGAGGTTTTCTGTATGATGCTGGCGGGGCGCGTGGGATTGGATGCGCCTGTCGTTTCCAAAGGCATGGCAG
GAAATACCGGATTCATTCTTGTTGAACGTTATGACCGTGTGCGCGAAGAGAATGGCAGGATTTTACGCTTGCATCAGGAA
GATTTCTGTCAGGCTCTGGGTGTGCCGCCGGAAATTAAATATGAATCGGAAGGTGGGCCGGGAATAGCCAGTTCACAGGC
GTTGATCCAGAATGTAACGCAGAGGCCGGCTGCCGATCGTCGTGCTTTTCAGCAAAGGGTGATTTTTCATTATCTGGTGG
GAAACGCGGATGCTCATGCCAAAAATTATTCCCTGCTATATCAGGGCAAGACGCCCGTTCTGGCTCCGGTTTACGATGTC
GTATGTACAGATGTATATTCTCTTGCAAAGAATATGGCCATGAAAATTGGTGAGCGCTCTCTGCCAGATACCATACGATT
GGAAGACTGGCAAAAAATGGTACCGGACACCCGGGTGGCAAAAAGGATATTGTCTGATGATTTATTACGAATGGCGAATG
GTATAGAAATCGAAGCGGACAGGCTTCTGGAAGAATTGAACGACCAAAATCTTTATCATCCGGTGTTGAAAAAAATCAGG
AGAACGATCGGTGTCCGGGTGCGAACGATTCAAAAGCTTATGGAAAAAATTGCCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8124.44 Da        Isoelectric Point: 10.5957

>AT72439 WP_005879938.1 NZ_CP019430:c1771477-1771253 [Oxalobacter formigenes OXCC13]
MTSVQNHIALGNLVRIERKRQKLTQEQLAALAGVGVRFLRELEKGKDSCRIGLAFSVMQTLGLSVDVSGRGDEK

Download         Length: 225 bp

>AT72439 NZ_CP019430:c1771477-1771253 [Oxalobacter formigenes OXCC13]
ATGACTTCAGTTCAAAATCATATTGCACTTGGCAATCTTGTTCGTATCGAACGGAAGCGTCAGAAGTTGACACAGGAGCA
ACTGGCTGCGCTTGCCGGTGTGGGTGTCCGGTTTTTACGTGAGCTGGAAAAAGGAAAGGACAGTTGTCGAATCGGTCTTG
CGTTTTCTGTCATGCAAACCCTTGGGTTGTCTGTGGATGTTTCCGGAAGAGGAGACGAAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB C3X8C7


Antitoxin

Source ID Structure

References