72434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2216748..2217337 Replicon chromosome
Accession NZ_CP019428
Organism Pseudomonas sp. R76

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PspR76_RS10190 Protein ID WP_159955071.1
Coordinates 2216748..2216921 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PspR76_RS10195 Protein ID WP_159955072.1
Coordinates 2216933..2217337 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspR76_RS10170 2211811..2212560 + 750 WP_159955067.1 phosphonate metabolism protein PhnP -
PspR76_RS10175 2213022..2214926 + 1905 WP_159955068.1 M10 family metallopeptidase C-terminal domain-containing protein -
PspR76_RS10180 2214938..2215819 - 882 WP_159955069.1 LysR family transcriptional regulator -
PspR76_RS10185 2215849..2216505 - 657 WP_159955070.1 AhpC/TSA family protein -
PspR76_RS10190 2216748..2216921 + 174 WP_159955071.1 type II toxin-antitoxin system HicA family toxin Toxin
PspR76_RS10195 2216933..2217337 + 405 WP_159955072.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PspR76_RS10200 2217344..2218540 - 1197 WP_159955073.1 MFS transporter -
PspR76_RS10205 2218719..2219342 + 624 WP_159955074.1 hypothetical protein -
PspR76_RS10210 2219479..2220483 - 1005 WP_159955075.1 sulfate ABC transporter substrate-binding protein -
PspR76_RS10215 2220588..2221412 - 825 WP_159955076.1 ion transporter -
PspR76_RS10220 2221444..2222316 - 873 WP_159955077.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(1-54)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6623.74 Da        Isoelectric Point: 10.8750

>T72434 WP_159955071.1 NZ_CP019428:2216748-2216921 [Pseudomonas sp. R76]
MIKELQEAGWVLDRVTGGHHIFTHRYNPYTIPVPHPKKDLPLGTVRSIRKRAGLFQF

Download         Length: 174 bp

>T72434 NZ_CP019428:2216748-2216921 [Pseudomonas sp. R76]
TTGATCAAGGAGCTGCAAGAGGCGGGTTGGGTGCTGGATCGGGTCACGGGCGGTCATCATATTTTTACTCACCGCTATAA
CCCGTACACGATCCCGGTGCCGCACCCCAAGAAGGACTTGCCCCTGGGCACCGTCAGAAGCATCAGGAAACGCGCCGGGC
TGTTTCAGTTTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14696.67 Da        Isoelectric Point: 4.4776

>AT72434 WP_159955072.1 NZ_CP019428:2216933-2217337 [Pseudomonas sp. R76]
MQYPMCIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGGPIPMPTSVANHHANEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT72434 NZ_CP019428:2216933-2217337 [Pseudomonas sp. R76]
ATGCAATACCCAATGTGTATCGAATGGGGCGACGACTTCACCGCCACCGGTATTCAGATCCCCGATATACCGGGCGCGGT
CACCGCCGGGGACAGCTTCGAAGAGGCGTACAACGCCGCCGTGGAAGTCGCGCACATCATGCTGCAGGAGATCGCCGCCG
AAGGCGGGCCGATTCCGATGCCCACCTCGGTGGCCAACCACCACGCGAACGAAGACTACGCCGGGATGGGCTGGGGGATG
TTGGAGTTGGACATCTCGCCCTATCTGGGCAAGACCGAGAAGGTCAATGTGACCTTGCCCGGTTATGTCATCCAGCGAAT
CGACCGTTATGTGCGTGAGCACAAGGTCAAAAGCCGCTCGTCATTTCTGGCGGATGCGGCCTTGGAGAAATTGGTGCGCT
CCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References