Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 664788..665384 Replicon chromosome
Accession NZ_CP019427
Organism Pseudomonas sp. S04

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PspS04_RS02850 Protein ID WP_159993515.1
Coordinates 665082..665384 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PspS04_RS02845 Protein ID WP_095171111.1
Coordinates 664788..665078 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspS04_RS02825 661055..663184 - 2130 WP_159993513.1 TonB-dependent copper receptor -
PspS04_RS02830 663275..663637 - 363 WP_159998722.1 DUF2946 domain-containing protein -
PspS04_RS02835 663749..664228 - 480 WP_095171161.1 copper chaperone PCu(A)C -
PspS04_RS02840 664290..664691 - 402 WP_095171109.1 DUF2946 domain-containing protein -
PspS04_RS02845 664788..665078 - 291 WP_095171111.1 putative addiction module antidote protein Antitoxin
PspS04_RS02850 665082..665384 - 303 WP_159993515.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PspS04_RS02855 665588..666316 - 729 WP_159993517.1 cobalt-precorrin-6A reductase -
PspS04_RS02860 666313..667410 - 1098 WP_159993519.1 cobalt-precorrin-5B (C(1))-methyltransferase -
PspS04_RS02865 667403..668614 - 1212 WP_159993521.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
PspS04_RS02870 668733..670055 + 1323 WP_159993523.1 precorrin-3B synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 590950..788047 197097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(5-95)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11426.95 Da        Isoelectric Point: 8.0396

>T72426 WP_159993515.1 NZ_CP019427:c665384-665082 [Pseudomonas sp. S04]
MIDFEQSDLFSDWLGSIKDTIGKARLLARLRAAEHGNFGDCEPVGEAVYEMRVHYGPGYRMYFTRKHRVVYLLLAGGDKS
TQKRDIQRAQSMARNIGSEE

Download         Length: 303 bp

>T72426 NZ_CP019427:c665384-665082 [Pseudomonas sp. S04]
ATGATCGACTTCGAACAGTCAGACCTATTTTCCGACTGGCTTGGCTCAATCAAGGACACCATCGGCAAGGCTCGCCTGCT
GGCGAGGCTTCGAGCTGCGGAACATGGCAACTTCGGTGATTGTGAACCTGTGGGTGAGGCTGTTTATGAAATGCGTGTCC
ATTACGGGCCTGGCTATCGAATGTACTTCACCCGCAAACATCGAGTGGTTTATCTGTTGTTGGCGGGAGGGGACAAGTCG
ACGCAAAAACGCGACATCCAGCGCGCGCAGTCGATGGCGCGAAACATCGGTAGCGAGGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10389.96 Da        Isoelectric Point: 5.0912

>AT72426 WP_095171111.1 NZ_CP019427:c665078-664788 [Pseudomonas sp. S04]
MAEQFSRFDVAQYLKTPEEMAAYLDACFEEDAGDGVLIRCALNDIARAKGMTQIARDTGLGRESLYKALGSTGNPEFATI
MKVMKALGLKLHATAA

Download         Length: 291 bp

>AT72426 NZ_CP019427:c665078-664788 [Pseudomonas sp. S04]
ATGGCTGAACAATTTAGCCGTTTCGACGTCGCCCAATACCTCAAGACACCTGAGGAAATGGCGGCCTACCTGGACGCCTG
CTTTGAAGAGGATGCAGGCGACGGTGTATTGATCCGTTGCGCGCTCAATGACATTGCGCGCGCCAAAGGCATGACACAGA
TCGCCCGCGACACCGGGTTGGGCCGTGAAAGCCTGTACAAGGCACTCGGCAGCACTGGCAATCCGGAATTCGCGACTATC
ATGAAGGTGATGAAGGCCCTGGGCCTCAAGCTTCACGCGACAGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References