Detailed information of TA system TA072422

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2408178..2408658
• Replicon: chromosome
• Accession: NZ_CP019426
• Organism: Pseudomonas sp. R84

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PspR84_RS10785
• Protein ID: WP_160057231.1
• Coordinates: 2408178..2408462 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4V6Q6W5
• Locus tag: PspR84_RS10790
• Protein ID: WP_034152589.1
• Coordinates: 2408452..2408658 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PspR84_RS10750	2403449..2403922	+	474	WP_038364886.1	type II secretion system GspH family protein	-
PspR84_RS10755	2403928..2404302	+	375	WP_160057228.1	type II secretion system GspH family protein	-
PspR84_RS10760	2404277..2404816	+	540	WP_160057229.1	type II secretion system protein	-
PspR84_RS10765	2404813..2405205	+	393	WP_127926659.1	curli production assembly/transport protein CsgE	-
PspR84_RS10770	2405202..2405633	+	432	WP_016987875.1	curli production assembly protein CsgF	-
PspR84_RS10775	2405662..2406522	+	861	WP_095111635.1	curli production assembly/transport protein CsgG	-
PspR84_RS10780	2407633..2408004	+	372	WP_160057230.1	hypothetical protein	-
PspR84_RS10785	2408178..2408462	-	285	WP_160057231.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PspR84_RS10790	2408452..2408658	-	207	WP_034152589.1	hypothetical protein	Antitoxin
PspR84_RS10795	2408934..2410385	-	1452	WP_160057232.1	curlin	-
PspR84_RS10800	2410413..2410877	-	465	WP_160057233.1	curlin	-
PspR84_RS10805	2410951..2413179	-	2229	WP_160057234.1	cadherin-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10839.62 Da
• Isoelectric Point: 10.5606

>T72422 WP_160057231.1 NZ_CP019426:c2408462-2408178 [Pseudomonas sp. R84]
MQIKWRPKARVELSKILKYIGERNFVAATALHTSVVKTTSALCWHPHLYRKGRSPGTREIVVSPNYLVVYQVADQIEIVS
ILHARQEYPRRDPG

Nucleotide

• Length: 285 bp

>T72422 NZ_CP019426:c2408462-2408178 [Pseudomonas sp. R84]
ATGCAGATTAAGTGGCGACCCAAGGCTCGGGTCGAACTCTCGAAAATCCTGAAGTACATTGGCGAACGAAATTTTGTAGC
GGCGACTGCACTTCACACGTCCGTCGTAAAAACTACATCTGCGCTTTGTTGGCATCCACACCTGTATCGCAAAGGCCGCT
CTCCTGGCACTCGAGAGATTGTGGTAAGCCCGAACTATCTCGTCGTTTATCAAGTGGCGGACCAAATTGAGATTGTGAGC
ATCTTGCATGCGCGTCAGGAGTACCCTCGACGCGACCCCGGTTAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7672.54 Da
• Isoelectric Point: 3.8068

>AT72422 WP_034152589.1 NZ_CP019426:c2408658-2408452 [Pseudomonas sp. R84]
MIDPSLIDPLCPVVSDLDPEEQAASYDRWFRAEVQASLDDPRPSIPHEQVMEEINALMESMRKSADAD

Nucleotide

• Length: 207 bp

>AT72422 NZ_CP019426:c2408658-2408452 [Pseudomonas sp. R84]
ATGATCGACCCGTCCTTGATCGACCCACTGTGCCCAGTCGTCTCGGATCTTGATCCTGAAGAACAGGCTGCGAGTTATGA
CCGCTGGTTCAGGGCGGAAGTACAAGCGTCTCTCGATGATCCGCGCCCGAGTATTCCCCATGAGCAAGTGATGGAGGAAA
TCAATGCCTTGATGGAATCAATGCGCAAAAGCGCTGATGCAGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A4V6Q6W5