Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 349109..349748 Replicon chromosome
Accession NZ_CP019426
Organism Pseudomonas sp. R84

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PspR84_RS01540 Protein ID WP_095190108.1
Coordinates 349109..349291 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PspR84_RS01545 Protein ID WP_160054810.1
Coordinates 349323..349748 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspR84_RS01505 344682..345059 + 378 WP_008080517.1 GNAT family N-acetyltransferase -
PspR84_RS01510 345056..345772 + 717 WP_160054804.1 AzlC family ABC transporter permease -
PspR84_RS01515 345751..346068 + 318 WP_007952614.1 AzlD domain-containing protein -
PspR84_RS01520 345985..346911 - 927 WP_123529788.1 LysR family transcriptional regulator -
PspR84_RS01525 347245..347652 + 408 WP_160054806.1 MbcA/ParS/Xre antitoxin family protein -
PspR84_RS01530 347664..348329 + 666 WP_160060038.1 RES family NAD+ phosphorylase -
PspR84_RS01535 348372..348653 - 282 WP_160054808.1 DUF3077 domain-containing protein -
PspR84_RS01540 349109..349291 + 183 WP_095190108.1 type II toxin-antitoxin system HicA family toxin Toxin
PspR84_RS01545 349323..349748 + 426 WP_160054810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PspR84_RS01550 349939..350223 + 285 WP_174244425.1 helix-turn-helix domain-containing protein -
PspR84_RS01555 350288..351445 - 1158 WP_160054812.1 AAA family ATPase -
PspR84_RS01560 351839..352987 - 1149 WP_160054814.1 integrase -
PspR84_RS01565 353288..353497 - 210 WP_160054816.1 hypothetical protein -
PspR84_RS01570 353695..354003 - 309 WP_160054818.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6795.85 Da        Isoelectric Point: 10.7304

>T72419 WP_095190108.1 NZ_CP019426:349109-349291 [Pseudomonas sp. R84]
MKYSEFRRWLKAQGVEFQNGKGSHFKVSLNGKSTVFPDHGAKEMGEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T72419 NZ_CP019426:349109-349291 [Pseudomonas sp. R84]
ATGAAGTACAGCGAGTTTCGGCGATGGTTGAAAGCCCAAGGCGTAGAGTTCCAAAACGGCAAGGGTAGCCACTTCAAGGT
TTCCTTGAACGGCAAATCAACTGTGTTTCCCGACCACGGAGCCAAGGAAATGGGCGAAGGGTTGAGAAAATCGATAATCA
AACAGCTGGGCCTCAAGGATTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15641.78 Da        Isoelectric Point: 4.5890

>AT72419 WP_160054810.1 NZ_CP019426:349323-349748 [Pseudomonas sp. R84]
MFEYALEVHEEPDSVWLSCAEIPEMHAVGDTLEQALDSAIDAIETALSIYVDDRRLIPTGQAGEQKSDVVLRLPTLTAAK
VALWNTLLESGVSKAELARRLGVQRPQVDRLVDFLHHSKIENVERALQQLGRRISLSVEAA

Download         Length: 426 bp

>AT72419 NZ_CP019426:349323-349748 [Pseudomonas sp. R84]
ATGTTCGAATATGCGTTGGAAGTTCACGAAGAGCCGGACAGTGTCTGGTTGTCCTGCGCAGAAATTCCAGAGATGCACGC
CGTTGGCGACACCCTTGAACAGGCGCTCGACAGTGCTATCGATGCCATCGAGACCGCCCTGTCGATCTACGTCGATGATC
GTCGATTGATTCCGACGGGGCAGGCGGGAGAACAGAAAAGTGACGTCGTGTTGCGTCTGCCTACGCTGACCGCAGCGAAG
GTTGCGCTTTGGAATACGCTCCTGGAGTCCGGTGTGAGCAAAGCCGAACTGGCGCGTCGGCTAGGAGTGCAAAGGCCTCA
GGTAGACCGACTGGTGGATTTTCTGCACCACTCAAAGATCGAGAATGTTGAGCGTGCGTTGCAACAGCTTGGGCGAAGGA
TCTCGCTTTCGGTTGAAGCAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References