Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 525066..525705 Replicon chromosome
Accession NZ_CP019401
Organism Planococcus faecalis strain AJ003

Toxin (Protein)


Gene name pemK Uniprot ID E7RK71
Locus tag AJGP001_RS02685 Protein ID WP_008432415.1
Coordinates 525355..525705 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5B0CU35
Locus tag AJGP001_RS02680 Protein ID WP_058386377.1
Coordinates 525066..525350 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AJGP001_RS02655 520792..521271 + 480 WP_071153531.1 PH domain-containing protein -
AJGP001_RS02660 521264..522775 + 1512 WP_071153545.1 PH domain-containing protein -
AJGP001_RS02665 522819..523427 - 609 WP_071153532.1 rhomboid family intramembrane serine protease -
AJGP001_RS02670 523496..523849 + 354 WP_058386379.1 holo-ACP synthase -
AJGP001_RS02675 523865..525022 + 1158 WP_058386378.1 alanine racemase -
AJGP001_RS02680 525066..525350 + 285 WP_058386377.1 hypothetical protein Antitoxin
AJGP001_RS02685 525355..525705 + 351 WP_008432415.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AJGP001_RS02690 525873..526700 + 828 WP_071153533.1 STAS domain-containing protein -
AJGP001_RS02695 526697..527062 + 366 WP_177167575.1 STAS domain-containing protein -
AJGP001_RS02700 527065..527466 + 402 WP_058386375.1 anti-sigma regulatory factor -
AJGP001_RS02705 527479..528480 + 1002 WP_078080119.1 PP2C family protein-serine/threonine phosphatase -
AJGP001_RS02710 528577..528906 + 330 WP_078080120.1 anti-sigma factor antagonist -
AJGP001_RS02715 528908..529378 + 471 WP_071153546.1 anti-sigma B factor RsbW -
AJGP001_RS02720 529356..530138 + 783 WP_058386371.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12880.97 Da        Isoelectric Point: 5.8817

>T72417 WP_008432415.1 NZ_CP019401:525355-525705 [Planococcus faecalis]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDDTLMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T72417 NZ_CP019401:525355-525705 [Planococcus faecalis]
TTGATTGTAAAACGCGGAGATGTTTTTTTTGCGGAATTATCGCCAGTCGTCGGGTCTGAGCAGGGTGGGACCCGACCTGT
ACTGGTGATTCAAAACGATATAGGGAATCGTTTTAGTCCAACTGTTATTATTGCAGCAATCACGGCGCAAATTCAAAAAG
CCAAATTACCGACTCATGTAGAAATCAACGCCAAGAAATACGGCTTTGAGCGCGATTCCGTTATTTTGCTAGAACAATTG
CGAACCATTGACAAGTCGCGACTGACCGACAAAATTACGCAGCTTGACGACACTTTGATGGAAAAAGTAGACGAAGCATT
AGAAATCAGCGTAGGTCTTGTTAAATTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10764.16 Da        Isoelectric Point: 6.3231

>AT72417 WP_058386377.1 NZ_CP019401:525066-525350 [Planococcus faecalis]
VYEKSKTKEVVVKMPKQFISELTTHSNEHVQESGDYIYVSTSRVTKNLYDSYHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHMTVRLVSGG

Download         Length: 285 bp

>AT72417 NZ_CP019401:525066-525350 [Planococcus faecalis]
GTGTACGAGAAGTCAAAGACAAAAGAAGTGGTTGTGAAAATGCCAAAGCAATTTATTTCAGAGTTGACAACTCATTCAAA
TGAGCATGTCCAAGAAAGTGGAGATTATATTTATGTTTCCACAAGCCGGGTGACAAAAAATCTGTATGACTCATATCATA
TTCGAGAAGCGATGATCAAAGGCTACGTGGAGATGTCTCAAATCAATCTATCGATTGCTTGTGAATGTTCTCACGCTGAG
TATGAAGCGGAGCATATGACTGTCCGACTCGTAAGCGGAGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7DUM1

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0CU35

References