72413

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1992052..1992613 Replicon chromosome
Accession NZ_CP019400
Organism Acidipropionibacterium acidipropionici strain WSH1105

Toxin (Protein)


Gene name mazF Uniprot ID A0A806VT27
Locus tag BWX38_RS09245 Protein ID WP_028700435.1
Coordinates 1992052..1992399 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID K7S105
Locus tag BWX38_RS09250 Protein ID WP_015071955.1
Coordinates 1992386..1992613 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWX38_RS17375 1987663..1988214 + 552 WP_015071949.1 zinc-binding dehydrogenase -
BWX38_RS09230 1988319..1988696 - 378 WP_076692651.1 L,D-transpeptidase -
BWX38_RS09235 1989226..1990773 - 1548 WP_051281579.1 glycoside hydrolase family 32 protein -
BWX38_RS09240 1990940..1991899 + 960 WP_015071953.1 PfkB domain-containing protein -
BWX38_RS09245 1992052..1992399 - 348 WP_028700435.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BWX38_RS09250 1992386..1992613 - 228 WP_015071955.1 ribbon-helix-helix domain-containing protein Antitoxin
BWX38_RS09255 1992769..1992960 + 192 WP_036936157.1 hypothetical protein -
BWX38_RS09260 1992938..1995079 + 2142 WP_028700434.1 NAD(+) synthase -
BWX38_RS09265 1995173..1995577 - 405 WP_015071959.1 nitrite reductase small subunit NirD -
BWX38_RS09270 1995604..1997589 - 1986 WP_198027851.1 nitrite reductase large subunit NirB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-35)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12562.56 Da        Isoelectric Point: 11.4911

>T72413 WP_028700435.1 NZ_CP019400:c1992399-1992052 [Acidipropionibacterium acidipropionici]
MIRGEVRLVDLDPARPGEVNKRRPAVLVSNDTANRTAARLGRGVVTVVPVTSNVTRVFPFQILLQADETGLRRDSKAQAE
QVRSVSVERIGPVLGMVPADLMSRIDDALRIHLGL

Download         Length: 348 bp

>T72413 NZ_CP019400:c1992399-1992052 [Acidipropionibacterium acidipropionici]
ATGATCCGCGGTGAGGTCCGGCTGGTCGATCTGGATCCGGCGCGCCCCGGCGAGGTGAACAAGCGACGTCCCGCCGTCCT
CGTGAGCAATGACACGGCGAACCGGACGGCCGCACGGCTGGGGCGGGGAGTGGTGACGGTGGTGCCGGTCACCAGCAACG
TCACCCGGGTCTTCCCCTTCCAAATCCTGCTTCAGGCGGACGAGACGGGGCTGCGGCGCGATTCCAAGGCCCAGGCCGAG
CAGGTCCGCTCGGTGTCGGTGGAACGGATCGGCCCGGTGCTCGGGATGGTGCCGGCTGATCTCATGAGCCGCATCGATGA
CGCGCTGAGAATCCACCTGGGGCTGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8161.01 Da        Isoelectric Point: 4.0941

>AT72413 WP_015071955.1 NZ_CP019400:c1992613-1992386 [Acidipropionibacterium acidipropionici]
MKLSVSLSKEQVETIDRYIRATGMRSRSAVIQKAIGMLGAPELEGDYAAAWDEWESGDAEAWESTAADGLGDDPR

Download         Length: 228 bp

>AT72413 NZ_CP019400:c1992613-1992386 [Acidipropionibacterium acidipropionici]
ATGAAACTCAGTGTCAGCCTGTCCAAGGAGCAGGTGGAGACCATCGACCGGTACATCCGTGCCACCGGGATGAGGTCGAG
GTCCGCGGTGATCCAGAAGGCGATCGGCATGCTCGGCGCCCCGGAGCTCGAGGGGGACTACGCCGCCGCCTGGGACGAGT
GGGAGTCCGGGGACGCCGAGGCCTGGGAGTCGACGGCCGCCGATGGGCTCGGCGATGATCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806VT27

Antitoxin

Source ID Structure
AlphaFold DB K7S105

References