Detailed information of TA system TA072412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1384421..1385061
• Replicon: chromosome
• Accession: NZ_CP019400
• Organism: Acidipropionibacterium acidipropionici strain WSH1105

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K7RZN5
• Locus tag: BWX38_RS06530
• Protein ID: WP_015071400.1
• Coordinates: 1384669..1385061 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K7S7C8
• Locus tag: BWX38_RS06525
• Protein ID: WP_015071399.1
• Coordinates: 1384421..1384672 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWX38_RS06510	1380357..1381289	+	933	WP_028700703.1	hydrogen peroxide-inducible genes activator	-
BWX38_RS06515	1381392..1382825	-	1434	WP_028700704.1	adenylosuccinate lyase	-
BWX38_RS06520	1382887..1384206	-	1320	WP_028700705.1	phosphoribosylamine--glycine ligase	-
BWX38_RS06525	1384421..1384672	+	252	WP_015071399.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BWX38_RS06530	1384669..1385061	+	393	WP_015071400.1	type II toxin-antitoxin system VapC family toxin	Toxin
BWX38_RS06535	1385263..1386549	-	1287	WP_015071401.1	adenylosuccinate synthase	-
BWX38_RS06540	1386754..1387620	-	867	WP_036936754.1	GNAT family N-acetyltransferase	-
BWX38_RS06545	1387681..1388382	-	702	WP_081685359.1	DUF3151 family protein	-
BWX38_RS06550	1388534..1388824	+	291	WP_148279567.1	metal-sensitive transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-82)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13574.31 Da
• Isoelectric Point: 3.9588

>T72412 WP_015071400.1 NZ_CP019400:1384669-1385061 [Acidipropionibacterium acidipropionici]
MIVDTSALVAVLTGEPDAEHLLDVMIGADRLALSAASLVEASVVLEARAGSEAVADLHALLADLDTEVLPCDETQAITAA
QAWSRFGKGRHPAALNLGDLFSYAAAITQGESLLFKGDDFPQTDIVVADR

Nucleotide

• Length: 393 bp

>T72412 NZ_CP019400:1384669-1385061 [Acidipropionibacterium acidipropionici]
ATGATCGTCGACACGTCTGCCCTGGTGGCCGTACTCACAGGAGAGCCCGACGCCGAGCACCTGCTTGACGTCATGATCGG
CGCCGACCGCCTGGCATTGAGCGCCGCCAGCCTGGTTGAGGCTTCTGTCGTTCTCGAGGCACGCGCTGGATCCGAGGCGG
TGGCCGATCTTCACGCGCTACTGGCCGACCTCGACACGGAAGTCCTGCCGTGTGACGAGACCCAGGCGATCACAGCAGCT
CAGGCATGGAGCCGTTTCGGGAAGGGGCGTCACCCTGCTGCGCTGAACCTCGGCGACTTGTTCTCATATGCCGCCGCAAT
TACTCAGGGAGAGTCACTTCTCTTCAAGGGCGACGACTTCCCACAAACCGACATCGTGGTAGCCGATCGGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9500.56 Da
• Isoelectric Point: 6.0829

>AT72412 WP_015071399.1 NZ_CP019400:1384421-1384672 [Acidipropionibacterium acidipropionici]
MALNIKDPDTDRLARELAEETGETLTSALHAALAERLTRVRRQHRVSSRPDLHHYIERARARAVLDDRDADEIIGYDENG
LPR

Nucleotide

• Length: 252 bp

>AT72412 NZ_CP019400:1384421-1384672 [Acidipropionibacterium acidipropionici]
ATGGCGCTCAACATCAAGGACCCGGACACCGACCGGCTGGCCCGTGAACTTGCAGAGGAGACCGGCGAGACCCTCACCTC
TGCGCTGCACGCCGCCCTGGCTGAACGCTTGACACGAGTGCGCCGTCAGCACCGGGTCTCCTCCCGGCCCGATCTGCATC
ACTACATCGAACGCGCGCGAGCCAGGGCCGTGCTCGATGATCGCGACGCCGACGAGATCATCGGCTATGACGAGAACGGC
CTGCCACGATGA

Structures

Toxin

• AlphaFold DB: K7RZN5

Antitoxin

• AlphaFold DB: K7S7C8