Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1542465..1542993 Replicon chromosome
Accession NZ_CP019399
Organism Pseudomonas chlororaphis strain R47

Toxin (Protein)


Gene name relE Uniprot ID A0A7S5LMJ4
Locus tag PchlR47_RS06960 Protein ID WP_038581545.1
Coordinates 1542465..1542764 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7S5HLJ1
Locus tag PchlR47_RS06965 Protein ID WP_038581543.1
Coordinates 1542754..1542993 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PchlR47_RS06940 1538259..1539041 - 783 WP_101281929.1 aldolase -
PchlR47_RS06945 1539201..1539743 + 543 WP_007922237.1 XRE family transcriptional regulator -
PchlR47_RS06950 1540066..1541085 - 1020 WP_009047445.1 DUF4917 family protein -
PchlR47_RS06955 1541243..1542391 + 1149 WP_038630803.1 L-threonine dehydrogenase -
PchlR47_RS06960 1542465..1542764 - 300 WP_038581545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PchlR47_RS06965 1542754..1542993 - 240 WP_038581543.1 ribbon-helix-helix protein, CopG family Antitoxin
PchlR47_RS06970 1543130..1543546 + 417 WP_009047448.1 fosfomycin resistance glutathione transferase -
PchlR47_RS06975 1543674..1544312 + 639 WP_016702101.1 LysE family translocator -
PchlR47_RS06980 1544424..1545764 + 1341 WP_016702102.1 sensor domain-containing diguanylate cyclase -
PchlR47_RS06985 1545902..1546426 + 525 WP_009047451.1 DUF4142 domain-containing protein -
PchlR47_RS06990 1546520..1547410 - 891 WP_038630805.1 phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-82)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11487.13 Da        Isoelectric Point: 10.8916

>T72407 WP_038581545.1 NZ_CP019399:c1542764-1542465 [Pseudomonas chlororaphis]
MHVEWLRSALKNLDDEAAYIAQDSPQAAAEFVKAILSSIQHLSRFPASGREGRLPGTREWVVPNRPYLIPYRVRQGRLQI
LRIFHTRRLPPAGWQDDRQ

Download         Length: 300 bp

>T72407 NZ_CP019399:c1542764-1542465 [Pseudomonas chlororaphis]
ATGCACGTTGAGTGGCTACGCAGCGCCCTCAAGAACCTCGATGACGAAGCCGCCTACATTGCACAGGACAGTCCTCAGGC
CGCCGCGGAATTCGTCAAAGCCATCCTGAGTAGCATTCAACACCTGAGCCGTTTTCCTGCCAGTGGTCGCGAAGGTCGCC
TGCCCGGTACCCGGGAGTGGGTGGTCCCCAATCGTCCTTACCTGATCCCCTACCGCGTACGTCAGGGACGCCTGCAGATA
CTGCGGATTTTCCACACCCGGCGCTTGCCGCCTGCCGGTTGGCAAGACGACCGCCAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8648.73 Da        Isoelectric Point: 4.5535

>AT72407 WP_038581543.1 NZ_CP019399:c1542993-1542754 [Pseudomonas chlororaphis]
MSVMSLRLPDDVADTLAHLAKATGRSKSFLAVDALREYLAREAWQINEIQKALTEAEAGDFASAEELDGVLNKWTGNAR

Download         Length: 240 bp

>AT72407 NZ_CP019399:c1542993-1542754 [Pseudomonas chlororaphis]
ATGTCCGTCATGTCCTTGCGCCTGCCCGATGATGTTGCCGATACCCTGGCTCACTTGGCCAAGGCGACAGGCCGCAGCAA
GTCATTCCTCGCTGTGGATGCACTGAGAGAATATCTGGCCCGCGAAGCCTGGCAAATCAACGAGATCCAGAAAGCCCTGA
CTGAAGCAGAGGCAGGCGACTTCGCCAGCGCCGAAGAGCTGGATGGCGTACTCAACAAATGGACTGGCAATGCACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S5LMJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7S5HLJ1

References