Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1412479..1413100 Replicon chromosome
Accession NZ_CP019397
Organism Pseudomonas sp. S19

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PspS19_RS06155 Protein ID WP_093412936.1
Coordinates 1412918..1413100 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PspS19_RS06150 Protein ID WP_159994179.1
Coordinates 1412479..1412886 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspS19_RS06125 1408444..1408947 + 504 WP_095167096.1 DUF4142 domain-containing protein -
PspS19_RS06130 1408954..1409364 - 411 WP_159994171.1 low affinity iron permease family protein -
PspS19_RS06135 1409563..1410648 + 1086 WP_159994173.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
PspS19_RS06140 1410817..1411545 - 729 WP_159994175.1 class I SAM-dependent methyltransferase -
PspS19_RS06145 1411703..1412473 + 771 WP_159994177.1 trans-aconitate 2-methyltransferase -
PspS19_RS06150 1412479..1412886 - 408 WP_159994179.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PspS19_RS06155 1412918..1413100 - 183 WP_093412936.1 type II toxin-antitoxin system HicA family toxin Toxin
PspS19_RS06165 1413625..1414509 - 885 WP_159994181.1 alpha/beta hydrolase -
PspS19_RS06170 1414821..1415513 - 693 WP_159994183.1 pseudouridine synthase -
PspS19_RS06175 1415546..1415764 - 219 WP_159994185.1 cysteine-rich CWC family protein -
PspS19_RS06180 1415757..1417244 - 1488 WP_159994187.1 sensor domain-containing diguanylate cyclase -
PspS19_RS06185 1417475..1417933 + 459 WP_095167115.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6752.92 Da        Isoelectric Point: 11.0197

>T72396 WP_093412936.1 NZ_CP019397:c1413100-1412918 [Pseudomonas sp. S19]
VNSRYLISQIVADGWYLVRVRGSHHHFKHPTKPGLVTVPHPKKDLLTKTAVSILQQALLS

Download         Length: 183 bp

>T72396 NZ_CP019397:c1413100-1412918 [Pseudomonas sp. S19]
GTGAACAGTCGATATTTGATCAGCCAAATCGTTGCAGACGGCTGGTATCTGGTGCGGGTCCGGGGCAGTCACCATCATTT
CAAACATCCAACCAAACCTGGATTGGTGACGGTTCCGCACCCGAAGAAGGATCTGCTGACCAAGACGGCAGTGAGCATCC
TGCAACAGGCCCTGTTGTCATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14719.60 Da        Isoelectric Point: 4.6008

>AT72396 WP_159994179.1 NZ_CP019397:c1412886-1412479 [Pseudomonas sp. S19]
MLYPIAISEGDDQHAWGVEVPDIPGCFSAGDDLDDAIAMAREAIEGHFEILAEDGSAIPPANRVTHHARNPQYAGVTWAL
VDIDVSKYLGKAQKLNITLPAYLLTRIDEYVLHHPEEKSRSGFLASAALKVLQQA

Download         Length: 408 bp

>AT72396 NZ_CP019397:c1412886-1412479 [Pseudomonas sp. S19]
ATGCTTTATCCAATTGCCATTTCAGAAGGCGATGACCAGCACGCCTGGGGCGTGGAAGTGCCGGATATTCCGGGGTGCTT
CTCGGCCGGTGATGACCTGGACGACGCCATCGCCATGGCACGTGAAGCCATCGAGGGGCACTTCGAGATCCTGGCCGAGG
ACGGTTCGGCGATTCCGCCAGCCAACAGGGTGACCCACCATGCGCGCAACCCGCAATATGCCGGCGTGACCTGGGCCTTG
GTCGACATCGACGTCAGCAAATACCTGGGCAAGGCGCAGAAACTCAATATCACCCTGCCCGCCTATCTGCTGACTCGCAT
CGACGAATACGTGCTGCACCACCCGGAAGAAAAAAGCCGCTCCGGCTTTCTGGCCTCGGCGGCGTTGAAGGTATTGCAGC
AGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References