Detailed information of TA system TA072396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1412479..1413100
• Replicon: chromosome
• Accession: NZ_CP019397
• Organism: Pseudomonas sp. S19

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PspS19_RS06155
• Protein ID: WP_093412936.1
• Coordinates: 1412918..1413100 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PspS19_RS06150
• Protein ID: WP_159994179.1
• Coordinates: 1412479..1412886 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PspS19_RS06125	1408444..1408947	+	504	WP_095167096.1	DUF4142 domain-containing protein	-
PspS19_RS06130	1408954..1409364	-	411	WP_159994171.1	low affinity iron permease family protein	-
PspS19_RS06135	1409563..1410648	+	1086	WP_159994173.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
PspS19_RS06140	1410817..1411545	-	729	WP_159994175.1	class I SAM-dependent methyltransferase	-
PspS19_RS06145	1411703..1412473	+	771	WP_159994177.1	trans-aconitate 2-methyltransferase	-
PspS19_RS06150	1412479..1412886	-	408	WP_159994179.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PspS19_RS06155	1412918..1413100	-	183	WP_093412936.1	type II toxin-antitoxin system HicA family toxin	Toxin
PspS19_RS06165	1413625..1414509	-	885	WP_159994181.1	alpha/beta hydrolase	-
PspS19_RS06170	1414821..1415513	-	693	WP_159994183.1	pseudouridine synthase	-
PspS19_RS06175	1415546..1415764	-	219	WP_159994185.1	cysteine-rich CWC family protein	-
PspS19_RS06180	1415757..1417244	-	1488	WP_159994187.1	sensor domain-containing diguanylate cyclase	-
PspS19_RS06185	1417475..1417933	+	459	WP_095167115.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6752.92 Da
• Isoelectric Point: 11.0197

>T72396 WP_093412936.1 NZ_CP019397:c1413100-1412918 [Pseudomonas sp. S19]
VNSRYLISQIVADGWYLVRVRGSHHHFKHPTKPGLVTVPHPKKDLLTKTAVSILQQALLS

Nucleotide

• Length: 183 bp

>T72396 NZ_CP019397:c1413100-1412918 [Pseudomonas sp. S19]
GTGAACAGTCGATATTTGATCAGCCAAATCGTTGCAGACGGCTGGTATCTGGTGCGGGTCCGGGGCAGTCACCATCATTT
CAAACATCCAACCAAACCTGGATTGGTGACGGTTCCGCACCCGAAGAAGGATCTGCTGACCAAGACGGCAGTGAGCATCC
TGCAACAGGCCCTGTTGTCATGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14719.60 Da
• Isoelectric Point: 4.6008

>AT72396 WP_159994179.1 NZ_CP019397:c1412886-1412479 [Pseudomonas sp. S19]
MLYPIAISEGDDQHAWGVEVPDIPGCFSAGDDLDDAIAMAREAIEGHFEILAEDGSAIPPANRVTHHARNPQYAGVTWAL
VDIDVSKYLGKAQKLNITLPAYLLTRIDEYVLHHPEEKSRSGFLASAALKVLQQA

Nucleotide

• Length: 408 bp

>AT72396 NZ_CP019397:c1412886-1412479 [Pseudomonas sp. S19]
ATGCTTTATCCAATTGCCATTTCAGAAGGCGATGACCAGCACGCCTGGGGCGTGGAAGTGCCGGATATTCCGGGGTGCTT
CTCGGCCGGTGATGACCTGGACGACGCCATCGCCATGGCACGTGAAGCCATCGAGGGGCACTTCGAGATCCTGGCCGAGG
ACGGTTCGGCGATTCCGCCAGCCAACAGGGTGACCCACCATGCGCGCAACCCGCAATATGCCGGCGTGACCTGGGCCTTG
GTCGACATCGACGTCAGCAAATACCTGGGCAAGGCGCAGAAACTCAATATCACCCTGCCCGCCTATCTGCTGACTCGCAT
CGACGAATACGTGCTGCACCACCCGGAAGAAAAAAGCCGCTCCGGCTTTCTGGCCTCGGCGGCGTTGAAGGTATTGCAGC
AGGCTTGA