Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 322735..323372 Replicon chromosome
Accession NZ_CP019397
Organism Pseudomonas sp. S19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PspS19_RS01355 Protein ID WP_159993192.1
Coordinates 322735..323142 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PspS19_RS01360 Protein ID WP_159993194.1
Coordinates 323142..323372 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PspS19_RS01330 318029..319258 - 1230 WP_159993186.1 methyltransferase -
PspS19_RS01335 319239..319928 - 690 WP_095167402.1 ABC transporter permease -
PspS19_RS01340 319925..320620 - 696 WP_159993188.1 ABC transporter permease -
PspS19_RS01345 320699..321454 - 756 WP_159993190.1 ABC transporter substrate-binding protein -
PspS19_RS01350 321468..322241 - 774 WP_095167396.1 ABC transporter ATP-binding protein -
PspS19_RS01355 322735..323142 - 408 WP_159993192.1 tRNA(fMet)-specific endonuclease VapC Toxin
PspS19_RS01360 323142..323372 - 231 WP_159993194.1 antitoxin Antitoxin
PspS19_RS01365 323553..324005 - 453 WP_159993196.1 hypothetical protein -
PspS19_RS01370 324011..324427 - 417 WP_159993198.1 hypothetical protein -
PspS19_RS01375 324467..325441 - 975 WP_095167390.1 alpha/beta fold hydrolase -
PspS19_RS01380 325509..326075 - 567 Protein_267 DUF1016 domain-containing protein -
PspS19_RS01385 326336..326785 + 450 WP_159993200.1 carboxypeptidase regulatory-like domain-containing protein -
PspS19_RS01390 326835..327914 - 1080 WP_159993202.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15044.50 Da        Isoelectric Point: 7.9256

>T72393 WP_159993192.1 NZ_CP019397:c323142-322735 [Pseudomonas sp. S19]
MLKYMLDTNICIFTIKNKPQIVREAFNRHNGQLCISAVTLMELIYGAEKSAAPEKNLAIIEGLAARLDVLPFDYEAAAHT
GMIRSELAKAGTPIGPYDHMIAGHARSRGFIVVTNNLREFQRIPGLRVEDWVHPA

Download         Length: 408 bp

>T72393 NZ_CP019397:c323142-322735 [Pseudomonas sp. S19]
ATGCTCAAATACATGCTCGACACCAATATCTGTATTTTCACCATCAAGAACAAACCGCAGATAGTGCGCGAAGCATTCAA
TCGTCATAACGGGCAATTGTGCATCAGCGCGGTCACTCTGATGGAGTTGATCTACGGTGCGGAAAAATCGGCCGCACCTG
AAAAGAACCTCGCCATTATCGAGGGGCTGGCGGCTCGTCTTGACGTCTTGCCGTTCGACTATGAAGCCGCTGCCCATACC
GGAATGATTCGCTCGGAACTTGCAAAAGCCGGGACCCCCATAGGTCCCTATGACCACATGATCGCCGGCCACGCACGCTC
CCGAGGTTTCATTGTGGTAACCAACAACCTTCGTGAATTCCAGCGGATTCCGGGATTGCGCGTCGAAGACTGGGTCCACC
CCGCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8540.56 Da        Isoelectric Point: 4.3719

>AT72393 WP_159993194.1 NZ_CP019397:c323372-323142 [Pseudomonas sp. S19]
MEQTTLFLSNRSQAVRLPKAVAMPADVKRVEVIAIGRARLITPAGEAWDSWFDGDTVSDDFMADREQPANQERESF

Download         Length: 231 bp

>AT72393 NZ_CP019397:c323372-323142 [Pseudomonas sp. S19]
ATGGAACAAACCACCCTTTTCCTGAGCAATCGCAGCCAGGCTGTCCGCTTGCCCAAGGCAGTCGCGATGCCCGCTGATGT
GAAGCGCGTTGAGGTCATTGCCATTGGCCGTGCGCGTCTCATCACCCCGGCCGGAGAAGCCTGGGACAGTTGGTTCGATG
GCGACACAGTGTCGGATGACTTTATGGCAGACCGTGAGCAGCCGGCCAATCAAGAGCGCGAGTCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References