72390

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 20769..21291 Replicon plasmid pXH992_2
Accession NZ_CP019395
Organism Escherichia coli strain XH992

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag BW707_RS26570 Protein ID WP_000220561.1
Coordinates 21010..21291 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag BW707_RS26565 Protein ID WP_000121743.1
Coordinates 20769..21020 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW707_RS26545 16933..17121 + 189 WP_000957857.1 hypothetical protein -
BW707_RS26550 17131..18330 + 1200 WP_000948429.1 IS91 family transposase -
BW707_RS26555 18504..18674 - 171 Protein_18 replication initiation protein -
BW707_RS26560 18695..19534 - 840 WP_024129959.1 replication initiation protein -
BW707_RS26565 20769..21020 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
BW707_RS26570 21010..21291 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BW707_RS26575 21530..21622 - 93 Protein_22 IS6 family transposase -
BW707_RS26580 21788..22987 - 1200 WP_000948429.1 IS91 family transposase -
BW707_RS26585 22997..23185 - 189 WP_000957857.1 hypothetical protein -
BW707_RS26590 23306..23974 + 669 Protein_25 replication initiation protein -
BW707_RS26595 23978..24424 + 447 WP_001074384.1 hypothetical protein -
BW707_RS26600 24492..24913 + 422 Protein_27 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mph(A) / oqxA / oqxB / aph(3')-IIa / dfrA12 / aadA2 / qacE / sul1 / rmtB / blaTEM-1B / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / fosA3 - 1..91319 91319
- inside IScluster/Tn mph(A) / oqxA / oqxB / aph(3')-IIa - 2575..22987 20412


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T72390 WP_000220561.1 NZ_CP019395:21010-21291 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T72390 NZ_CP019395:21010-21291 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT72390 WP_000121743.1 NZ_CP019395:20769-21020 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT72390 NZ_CP019395:20769-21020 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References